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二氮嗪对大鼠缺血再灌注损伤脑组织线粒体ATP酶活性的影响 被引量：7

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摘要 目的探讨线粒体ATP敏感性钾通道开放剂二氮嗪对大鼠局灶性脑缺血再灌注损伤脑组织线粒体ATP酶活性的影响。方法采用改良线栓法建立大鼠局灶性大脑中动脉缺血再灌注损伤模型。将21只Wistar雄性大鼠随机分为假手术组(N组)、缺血再灌注组(IR组)、二氮嗪干预组(DZ组)。缺血1 h再灌注24 h后留取标本,测定脑组织线粒体Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活性的变化。结果与假手术组比较,缺血再灌注组Na+-K+-ATPase、Ca2+-Mg2+-ATP酶活性明显降低(P<0.05);二氮嗪干预组Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活性均较缺血再灌注组有不同程度的提高(P<0.05)。结论二氮嗪预处理能通过提高脑组织线粒体Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活性,减轻脑缺血再灌注损伤,保护神经元线粒体的功能,有效维持大脑能量代谢,发挥脑保护作用。
作者 王玉凤 李光来
机构地区 山西医科大学 山西医科大学第二附属医院
出处 《中西医结合心脑血管病杂志》 2011年第3期337-338,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词 二氮嗪 缺血再灌注 NA+-K+-ATP酶 Ca2+-Mg2+-ATP酶
分类号 R743 [医药卫生—神经病学与精神病学] R285.5 [医药卫生—中药学]
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参考文献10

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二级参考文献8

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中西医结合心脑血管病杂志
2011年 第3期

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