摘要
溶脲脲原体（Ｕｒｅａｐｌａｓｍ ａ Ｕｒｅａｌｙｔｉｃｕｍ ，Ｕ．Ｕ．）是泌尿生殖道感染的常见病原体，在Ｕ．Ｕ．上行性感染的动物模型中，大鼠睾丸出现明显的病理损伤。本文主要探讨Ｕ．Ｕ．感染（或作用）对小鼠Ｔ、Ｂ淋巴细胞功能的影响。体外实验，以对数生长期的Ｕ．Ｕ．、热灭活Ｕ．Ｕ．和Ｕ．Ｕ．上清（不含Ｕ．Ｕ．）感染（或作用）小鼠Ｔ淋巴细胞（脾细胞来源），采用ＭＴＴ法检测Ｔ淋巴细胞的增殖活性。体内实验，以上述Ｕ．Ｕ．感染（或作用）正常ＢＡＬＢ／ｃ小鼠，于ｄ５用ＳＲＢＣ免疫各小鼠，免疫后ｄ５测定各小鼠血清抗ＳＲＢＣ抗体凝集效价。结果表明：对数生长期的Ｕ．Ｕ．及热灭活Ｕ．Ｕ．和Ｕ．Ｕ．上清均能明显抑制小鼠Ｔ淋巴细胞的增殖和Ｂ淋巴细胞产生特异性抗体的能力，与对照组相比，有显著差异，Ｐ＜ ０．０１或０．０５。提示，Ｕ．Ｕ．感染可直接影响Ｔ淋巴细胞和Ｂ淋巴细胞的功能。
Ureaplasma Urealyticum (U.U.) is one of the common pathogens in the urogenital tract.It has been verified that U.U. infection could lead to significant pathologic damage in testis in animal model of ascending U.U. infection.In this paper,we reported the effect of U.U. on proliferation of T lymphocytes (from spleen) in mouse and on antibody production by normal BALB/c mice.It has been shown that living U.U. at logarithmic growth phase and the heat inactivated U.U. as well as U.U. supernatant (having no U.U.) can inhibited the proliferation of T lymphocytes in mouse (from spleen,P<0.01) and the antibody production by normal BALB/c mouse (P<0.01 or P<0.05).It has been suggested that the U.U. infection can impair the function of the T,B lymphocytes in mouse.
出处
《生殖与避孕》
CSCD
北大核心
1999年第5期280-284,共5页
Reproduction and Contraception
关键词
溶脲脲原体
T细胞
细胞增殖
Β细胞
抗体效价
Ureaplasma urealyticum
T lymphocyte
Cell proliferation
B Lymphocyte
Antibody titer
