摘要
目的探讨应用超声造影评价肝硬化门脉高压的可行性,寻求无创评价门脉高压的新方法。方法 17例肝硬化门脉高压患者(病例组)、10例健康人(正常对照组)接受超声造影检查,应用QLAB分析软件,将肝实质作为感兴趣区绘制时间-强度曲线,计算肝动脉灌注时间Ta,肝实质灌注达峰时间Tpeak,门静脉灌注时间Tp(Tp=Tpeak-Ta),肝动脉灌注强度Ia,肝实质峰值强度Ipeak,门静脉灌注强度Ip(Ip=Ipeak-Ia),肝动脉-峰值强度比Ia/Ipeak,肝动脉-门静脉灌注强度比Ia/Ip。比较两组间各指标有无差异,并进行受试者工作特征曲线分析。结果病例组的Tpeak、Tp较正常对照组缩短(P<0.01),Ia/Ipeak、Ia/Ip病例组大于正常对照组(P<0.01,P<0.05)。Tpeak、Tp、Ia/Ipeak、Ia/Ip诊断肝硬化门脉高压的敏感度分别为76.5%、82.4%、76.5%、76.5%,特异度均为90.0%。结论超声造影可用于无创评价肝硬化门脉高压,效果优于CT、MR等。
Objective To discuss the feasibility of evaluating the pressure for portal vein of cirrhotic patients by contrast-enhanced ultrasound.Methods A total of 16 patients with cirrhotic portal hypertension and 10 healthy subjects as controls were given contrast-enhanced ultrasound examination,and time-intensity curves were drawn as the regions of interest located in liver parenchyma by using QLAB analyzing software.The parameters for peak intensity of arterial perfusion（Ia）,peak intensity of total perfusion（Ipeak）,intensity of portal venous perfusion（Ip）,the ratio of arterial perfusion and total perfusion（Ia /Ipeak）,the ratio of arterial perfusion and portal venous perfusion（Ia /Ip）,arrival time to the peak of arterial perfusion（Ta）,arrival time to the peak of total perfusion（Tpeak）,lasting time of portal venous perfusion（Tp） were compared.Results Tpeak,Tp were smaller,while Ia/Ipeak,Ia/Ip were bigger in patients than those in control group with statistical significance.Conclusion The contrast-enhanced ultrasound could be used as a non-invasive method for evaluating cirrhotic portal hypertension,which is better than CT and MR.
出处
《中华医学超声杂志（电子版）》
2010年第9期28-30,共3页
Chinese Journal of Medical Ultrasound(Electronic Edition)
基金
首都医科大学基础临床合作基金(007JL23)
关键词
超声检查
造影剂
肝硬化
门静脉高压
Ultrasonography
Contrast media
Liver cirrhosis
Portal hypertension
