摘要
随着表观遗传学的发展，越来越多的研究证实DNA甲基化与肿瘤的发生关系密切。分泌型卷曲相关蛋白（sFRP）基因甲基化可导致该基因表达的沉默，使得对Wnt信号通路的抑制作用减弱，促进肿瘤特别是大肠癌的发生与发展。当重新恢复sFRP的功能后，Wnt通路活性受到抑制，进而抑制了肿瘤的形成与进展，并促进肿瘤细胞凋亡的发生。因此sFRP基因家族甲基化与大肠癌的发生、发展关系密切。所以通过检测sFRP基因的甲基化对大肠癌进行早期筛查有望成为诊断大肠癌的一种新途径。
With the development of epigenetics, more and more studies have confirmed that DNA methylation is closely related with the tumorigenesis. Secreted frizzled-related protein （sFRP） gene methylation can result in the silence of gene expression, decrease in the inhibition of the Wnt signal pathway and promoting the occurrence and progress of tumor, especially in the colorectal cancer. When the function of sFRP recover, the activity of Wnt signal pathway is inhibited, thereby inhibiting formation and progress of tumor and promoting apoptosis of tumor cell. sFRP gene family methylation is closely related with the occurrence and progress of colorectal cancer. Therefore, the detection of SFRPs methylation is expected to be a new way for colorectal cancer early screening.
出处
《肿瘤研究与临床》
CAS
2010年第12期862-864,共3页
Cancer Research and Clinic
