摘要
目的 比较不同剂量甲基强的松龙治疗手足口病并发脑膜脑炎的疗效,方法将100例重症手足口病并发脑膜脑炎患儿随机分为两组,小剂量组50例（甲基强的松龙1～2mg/kg/d.静脉滴注,连用3～5d）和大剂量组50例（甲基强的松龙10～20mg/kg/d,静脉滴注,连用3d,再根据病情减量）.治疗后,比较两组患儿的发热持续时间、神经系统症状和体征恢复时间、住院天数及生命体征和血糖值.结果 两组患儿在发热持续时间、神经系统受累持续时间、住院时间等方面比较差异无统计学意义（P〉0.05）;而大剂量组患儿的心率、呼吸频率、血压和血糖均明显高于小剂量组,差异有统计学意义（P〈0.05）.结论 联合应用大剂量甲基强的松龙治疗手足口病并发脑膜脑炎相比小剂量法未明显改善患儿的临床症状及缩短病程,大剂量应用可增加患儿药物不良反应.
Objective To compare therapeutic effects of different dose methylprednisolone（MP） in treating hand-foot-mouth disease（HFMD） complicated by viral meningoencephalitis.Methods We divided randomizedly 100 children with hand-foot-mouth disease complicated by viral meningoencephalitis into two groups：The lowdose group（n=50） accepted intravenous injection of MP（l -2mg/kg/d,3 -5d）.The large-dose group（n=50） received pulse therapy of MP（10 ～ 20mg/kg/d on day I to 3,and thereafter decrement according to patient＇s condition）.The febrile duration,CNS involvement duration,time of staying in hospital,vital signs and serum glucose in two groups were compared after treatment. Results The febrile duration,CNS involvement duration and time of staying in hospital in two groups were not signinficantly different（P〉0.05）.But,in the large-dose group,the heart rate, breathing rate,blood pressure and serum glucose were much higher than in the low-dose group,which demonstrated a signifiant difference（P〈0.05）. Conclusion High dose methylprednisolone impaction in the treatment of hand-foot-mouth disease complicated by viral meningoencephalitis could not improve clinical symptoms and shorten the course.The large dosage of MP therapy could increase medicinal side effects.
出处
《中国血液流变学杂志》
CAS
2010年第4期644-646,共3页
Chinese Journal of Hemorheology
关键词
手足口病
病毒性脑膜脑炎
甲基强的松龙
治疗
Hand,foot and mouth disease
viral meningoencephalitis
methylprednisolone
treatment
