期刊文献+

比索洛尔联合培哚普利治疗慢性收缩性心力衰竭的疗效观察 被引量:6

Assessing the effect of perindopril combined with bisoprolol on chronic congestive heart failure
下载PDF
导出
摘要 目的观察比较比索洛尔和培哚普利联合应用与单用培哚普利对慢性收缩性心力衰竭患者的疗效。方法将75例慢性收缩性心力衰竭的患者随机分为培哚普利组(A组)37例和比索洛尔加培哚普利组(B组)38例,比较2组治疗前后心率、血压、心功能、左室舒张末内径(LVDd)、左室射血分数(LVEF)、心排出量(CO)、每搏量(SV)、A峰/E峰比值(A/E比值)、小轴缩短率(FS)。结果 2组患者治疗后血压、心率均下降(P<0.01),B组心率较A组明显下降,差异有统计学意义(P<0.01);心功能均明显改善(P<0.01),B组较A组改善更明显(P<0.01)。A组、B组治疗前后LVDd无明显变化(P>0.05);A/E比值2组均明显下降(P均<0.01),B组优于A组(P<0.01);2组CO、SV均明显上升(P均<0.01),组间差异无统计学意义(P>0.05);2组LVEF均明显上升(P均<0.01),B组优于A组(P<0.05)。结论培哚普利联合比索洛尔更能改善慢性收缩性心力衰竭患者的预后。 Objective To observe and compare the effect of perindopril plus bisoprolol and perindopril on chronic congestive heart failure(CHF).Methods 75 cases of CHF were randomly divided into control group(group A,37 cases) and treatment group(group B,38 cases).Heart rate,blood pressure,heart function,LVDd,LVEF,CO,SV,A/E rate and FS between the two groups on the time point of before and after the treatment were compared.Results The blood pressure had declined significantly after treatment in the two groups(P0.01 ),the heart rate had declined significantly in group B compared with group A(P0.01).The heart function was improved significantly after treatment in the two groups(P0.01), and the improvement in group B was more significant than that in group A(P0.01 ).The LVDd didn' t show significant difference between the two groups at the time point of before and after treatment(P0.05).The A/E rate significantly declined after treatment in the two groups(P0.01 ),group B was better than that of group A(P0.01 ).CO and SV significantly improved after treatment both in the two groups(P0.01),but didn't show significant difference(P0.05 ) between the two groups.The LVEF significantly improved after treatment in the two groups(P0.01 ),and group B was better than that of group A(P0.05).Conclusion The treatment of combining perindopril and bisoprolol is more effective than only use perindopril in improving the prognosis of the patients with CHF.
作者 梁伟东 钟毅
出处 《疑难病杂志》 CAS 2011年第3期165-167,共3页 Chinese Journal of Difficult and Complicated Cases
关键词 心力衰竭 慢性 收缩性 比索洛尔 培哚普利 Heart failure chronic congestive Bisoprolol Perindopril
  • 相关文献

参考文献15

二级参考文献91

  • 1董琦,魏梅,刘坤申.醛固酮受体拮抗剂在慢性心力衰竭中的应用[J].中华内科杂志,2005,44(7):545-547. 被引量:13
  • 2戴秋艳,严轶文,张治,孙宝贵.急性心肌梗死再灌注后近期血管内皮祖细胞相关功能基因的变化[J].中华心血管病杂志,2006,34(7):620-624. 被引量:4
  • 3周素平,杨成明.炎症和心力衰竭[J].心血管病学进展,2007,28(3):493-496. 被引量:25
  • 4Cleland JGF,Swedberg K. Carvedilol for heart failure with care [J]. Lancet, 1996,347 : 1109-1120.
  • 5Givertz MM, Colucci WS. New targets forheart-failure therapy: Endothelin, inflammatory cytokines,and oxidative stress[J].Lancet, 1998,352(Suppl 1):34-38.
  • 6Packer M,Cohn JN.Consensusre commendations for themanagement of chronic heart failure[J].Am J Cardiol,1999,83(Suppl 2A): 1A-38A.
  • 7Charlap S,Lichstein E,William H,et al. Beta-Adrenergic blocking drugin the treatment of Congestive heart failure[J].Med Clin North Am,2001,73(2): 373-385.
  • 8Packer M, Bristow MR, Cohn JN,et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group[J].N Eng J Med,1996,334(21): 1349-1355.
  • 9Lechat EAdrenergie.beta-blockers and heart failure[J].Areh Mal Coeur Vaiss, 1995,88(4 Suppl):611.
  • 10Heper G,Korkmaz ME,Kilic A.Reperfusion arrhythmias:are they only a marker of epicardial reperfusion or continuing myocardial ischemia after acute myocardial infarction?Angiology,2008,58:663-670.

共引文献1336

同被引文献38

引证文献6

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部