期刊文献+

类风湿关节炎与动脉粥样硬化的关系 被引量:15

下载PDF
导出
摘要 类风湿关节炎患者早期死亡风险增高,心血管疾病是其主要的死亡原因。与一般人群相比,类风湿关节炎患者心血管疾病发病风险明显增加。类风湿关节炎伴随的全身炎症反应逐渐被认为在动脉粥样硬化进展中起到非常重要的作用,可导致脂质异常、氧化应激增加、内皮功能障碍、动脉僵硬度增加、胰岛素抵抗加重等促进粥样斑块进展。此外,类风湿关节炎的异常免疫反应(包括细胞免疫和体液免疫)以及一些抗风湿药物的使用及基因易感性也与动脉粥样硬化进展有关。
作者 薛超 胡大一
出处 《国际心血管病杂志》 2011年第2期82-85,共4页 International Journal of Cardiovascular Disease
  • 相关文献

参考文献22

  • 1Shoenfeld Y, Gerli R, Doria A, et al. Accelerated atherosclerosis in autoimmune rheumatic diseases [J]. Circulation, 2005, 112(21) :3337-3347.
  • 2Gonzalez A, Maradit-Kremers H, Crowson CS, et al. Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non rheumatoid arthritis patients[J]. Ann Rheum Dis, 2008, 67(1) : 64-69.
  • 3Gonzalez-Gay MA, Gonzalez-Juanatey C, Lopez-Diaz MJ, et al. HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis[J]. Arthritis Rheum, 2007,57(1): 125 -132.
  • 4Georgiadis AN, Papavasiliou EC, Lourida ES, et al. Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: effect of early treatment - a prospective, controlled study[J]. Arthritis Res Ther, 2006, 8(3) : R82.
  • 5White D, Fayez S, Doube A. Atherogenic lipid profiles in rheumatoid arthritis[J].NZ Med J,20(/6,119(1240) : U2125.
  • 6Van Lenten BJ, Reddy ST, Navab M, et al. Understanding changes in high density lipoproteins during the acute phase response[J].Arterioseler Thromb Vase Biol, 2006,26 (8) : 1687-1688.
  • 7McMahon M, Grossman J, FitzGerald J, et al. Proinflam- matory high-density lipoprotein as a biomarker for atheroselerosis in patients with systemic lupus erythematosus and rheumatoid arthritis[J ]. Arthritis Rheum, 2006,54 (8) : 2541-2549.
  • 8Ablin JN, Boguslavski V, Aloush V, et al. Effect of anti- TNF alpha treatment on circulating endothelial progenitor ceils (EPCs) in rheumatoid arthritis[J]. Life Sci, 2006, 79(25) : 2364-2369.
  • 9Roman MJ, Devereux RB, Schwartz JE, et al. Arterial stiffness in chronic inflammatory diseases[J]. Hypertension, 2005,46(1): 194-199.
  • 10Liang CP, Han S, Senokuchi T, et al. The macrophage at the crossroads of insulin resistance and atherosclerosis[J]. Circ Res, 2007, 100(11): 1546 -1555.

同被引文献152

引证文献15

二级引证文献35

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部