期刊文献+

JAK-STAT信号通路及其在肝损伤中的作用 被引量:3

下载PDF
导出
摘要 细胞内存在着多种信号转导方式和途径,各种方式和途径间又有多个层次的交叉调控,是一个十分复杂的网络系统。1994年Darnell[1]等在研究干扰素(IFN-α和IFN-γ)如何诱导基因转录激活时发现了细胞因子信号传导途径JAK-
作者 李烨 邓存良
出处 《山东医药》 CAS 北大核心 2011年第7期109-111,共3页 Shandong Medical Journal
  • 相关文献

参考文献15

  • 1Darnell JE Jr, Kerr IM, Stark GR. JAK-STAT pathways and transcription activation in response to IFN and other extracellular signa- ling proteins[ J]. Science, 1994,264(5164) : 1415-1421.
  • 2Nobori K, Munehisa Y. Intracellar signaling pathways for cardiac Hy- pertrophy: ERK ,JAK-STAT,S6 kinase[ J]. Nippon Rinsho,2007,65 (4) :196-200.
  • 3Rawlings JS, Rosier KM, Harrison DA. The JAK/STAT signaling pathway[ J]. Journal of Cell Science ,2004,1 ( 17 ) : 1281-1283.
  • 4Kisseleva T, Bhattaeharya S, Braunstein J, et al. Signaling through the JAK/STAT pathway: recent advances and future challenges[ J ]. Gene,2002,285 ( 1 ) :1-24.
  • 5Suzuki S,Tanska K, Nogawa S, et al. Phosphorylation of signal transducer and activator of transcription-3 ( STAT-3 ) after ischemia and reperfusion in liver transplantation in rats [ J]. Am J Transplant, 2006,6(9) :2013-2022.
  • 6丁忠阳,张峰,蔡兵,王学浩,王彤.抑制JAK/STAT信号通路对大鼠肝移植缺血再灌注损伤的影响[J].实用医学杂志,2008,24(21):3649-3651. 被引量:3
  • 7Bautista D, Bermudez-Silva FJ, Lasarte J J, et al. Liver expression of proteins controlling interferon-mediated signalling as predictive factors in the response to therapy in patients with hepatitis C virus infection [ J]. J Patho1,2007,213 (3) :347-355.
  • 8Aoudjehane L, Pissaia AIR, Scatton O, et al. Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway [ J ]. Lab Invest, 2008,88 ( 9 ) :973-985.
  • 9Lin W,Choe WH,Hiasa Y,et al. Hepatitis C Virus Expression Suppresses Interferon Signaling by Degrading STATI[ J]. Gastroenterolo- gy, 2005, 128(4) : 1034-1041.
  • 10Cao Q, Mak KM, Lieber CS. Lepfin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells [ J]. J Hepato1,2007,46( 1 ) : 124-133.

二级参考文献38

共引文献50

同被引文献30

  • 1Rawlings J S, Rosler K M, Harrison D A. The JAK/STAT signalingpathway[J]. J Cell Sci, 2004(117):1281-1283.
  • 2Darnell J E Jr. Studies of IFN-induced transcriptional activation uncoverthe Jak-Stat pathway[J]. J Interferon Cytokine Res,1998,18(8):549-554.
  • 3Mikhail A Kolpakov, Rachid Seqqat, Khadija Rafiq, et al.Pleiotropic Effects of Neutrophils on Myocyte Apoptosis and LeftVentricular Remodeling During Early Volume Overload[J]. J Mol CellCardiol,2009,47(5): 634-645.
  • 4Stephanou A, Brar BK, Scarabelli TM, et al. Ischemia-induced STAT-1expression and activation play a critical role in cardiomyocyte apoptosis[J].J Biol Chem,2000,275(14):10002-10008.
  • 5Ahn YH, Lee G, Kang SK. Molecular insights of the injured lesionsof rat spinal cords: inflammation, poptosis, and cell survival[J]. BiochemBiophys Res Commun,2006,348(2):560-570.
  • 6Suzan Dziennis,Nabil J, Alkayed. Role of Signal Transducer andActivator of Transcription 3 in Neuronal Survival and Regeneration[J].Rev Neurosci,2008,19(4-5):341-361.
  • 7Chin YE, Kitagawa M, Kuida K, et al. Activation of the STAT signalingpathway can cause expression of caspase I and apoptosis[J]. Mol CellBiol.,1997,19(17):5328-5337.
  • 8Kumar A, Commane M, Flickinger TW, et al. Defective TNF-alphainducedapoptosis in STAT1-null cells due to low constitutive levels ofcaspases[J].Science,1997,278(5343):1630-1632.
  • 9Takagi Y, Harada J, Chiarugi A, et al. STAT1 is activated in neuronsafter ischemia and contributes to ischemic brain injury[J].J Cereb BloodFlow Metab,2002,22(11):1311-1318.
  • 10Lepiller Q,Abbas W,Kumar A, et al. HCMV activates the IL-6-JAKSTAT3axis in HepG2 cells and primary human hepatocytes[J]. PLoSOne,2013,8(3): e59591.

引证文献3

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部