摘要
目的探讨血清维生素D水平与中老年人生活质量的关系。方法 2009年9~11月在本院查体中心随机抽取济南市区机关事业单位167例中老年人,45~85岁,平均（61.02±10.06）岁。据25-羟维生素D（25OHD）水平分为3组：维生素D不足组（25OHD〈49.9nmol/L）,维生素D临界值组（25OHD=50~74.9nmol/L）,维生素D正常组（25OHD≥75nmol/L）。用酶联免疫吸附法（ELISA）测定血25OHD水平。采用SF-36量表对生活质量进行评价。结果血清25OHD水平为（54.21±19.88）nmol/L,维生素D正常者仅占18.0%。男、女25OHD水平分别为（58.13±19.07）nmol/L、（51.24±20.07）nmol/L,两者差异有统计学意义（P〈0.05）。〈60岁和≥60岁的人群25OHD水平分别为（58.82±19.34）和（49.54±19.43）nmol/L,两者差异有统计学意义（P〈0.01）。在生理功能、生理职能、躯体疼痛、总体健康、社会功能、活力、精神健康7个维度中,维生素D不足组得分低于维生素D临界值组及维生素D正常组得分,差异有统计学意义（P〈0.05）。Pearson相关分析示25OHD水平与生活质量各维度评分均呈正相关（P均〈0.05）。多元逐步回归分析显示维生素D对生活质量各维度评分影响较大。结论中老年人群普遍存在维生素D不足,女性较男性重,老年人较中年人重。血清25OHD水平与中老年人的生活质量呈正相关。应合理补充维生素D,并使其维持在适当水平。
Objective：To assess the correlation of serum 25-hydroxyvitamin D（25OHD） and the quality of life in middle-aged and older people.Methods：A total of 167 middle-aged and older people,from 45 to 85 years old with a mean age of 61.02±10.06 in Jinan institutions,were recruited from September to November 2009.Serum 25OHD was categorized into 3 groups： 49.9 nmol/L as the insufficient group,50-74.9 nmol/L as the borderline group,and ≥75 nmol/L as the normal group.Serum 25OHD levels were measured by ELISA and the SF-36 form was adopted to investigate the quality of life.Results：The mean 25OHD concentration was（54.21±19.88）nmol/L,while Vitamin D was detected as normal in 18.0% of the population.The 25OHD concentration of females and males were（58.13±19.07）nmol/L and（51.24±20.07） nmol/L,respectively.The difference was significant（P0.05）.The 25OHD concentration of people below and above 60 yrs old were（58.82±19.34） and（49.54±19.43） nmol/L,respectively.The difference was also significant（P0.01）.People with insufficient vitamin D received lower scores than the other two groups in seven dimensions： physical functioning（PF）,role-physical（RP）,bodily pain（BP）,general health（GH）,vitality（VT）,social functioning（SF）,and mental health（MH）（P0.05）.Positive correlation between Vitamin D and the scores of the quality of life was found by Pearson analysis（P0.05）.Stepwise multiple linear regression showed that vitamin D was the main factor affecting the quality of life.Conclusion：25OHD insufficiency is prevalent in middle-aged and older people,especially in the elderly and females.Lower serum 25OHD concentration in middle-aged and older people are associated with poorer quality of life.More attention should be paid to vitamin D supplementation in these populations.
出处
《山东大学学报（医学版）》
CAS
北大核心
2011年第2期1-4,8,共5页
Journal of Shandong University:Health Sciences
基金
民政部老年学和老年医学"十一五研究计划"(民人教科字[2008]47-1)
