摘要
目的:评价冬凌草水提物治疗慢性咽炎的临床疗效及其安全性。方法:将102例慢性咽炎患者随机分为干预组(n=51)和安慰剂组(n=51),采用双盲法给予受试物,每日1次,每次220 mL,30 d为1个疗程。试验前后分别进行常规体检,观察咽部临床症状,检查咽部体征。结果:患者饮用冬凌草水提物和安慰剂30 d后,干预组主要临床症状、体征改善率分别为67.31%和61.54%,安慰剂组主要临床症状、体征改善率分别为19.23%和11.54%,两者差异有统计学意义(P<0.05);试验前干预组和安慰剂组主要临床症状积分、体征积分差异无统计学意义(P>0.05),30 d后干预组主要临床症状积分、体征积分降低,与自身试验前及安慰剂组比较,差异有统计学意义(P<0.05)。结论:冬凌草水提物对慢性咽炎患者安全有效。
Objective To evaluate the clinical therapeutic effect of rabdosia rubescens aqueous extract on chronic pharyngitis and its safty.Methods One hundred and two patients suffered from chronic pharyngtis were randomly divided into an interventional group（n=51） and a placebo group（n=51）.These volunteers were given 220 mL test materials once a day double-blindly for 30 days.All patients took routine physical examinations,and their throat symptom and pharynx signs were observed before and after the experiment.Results After the patients had consumed rabdosia rubescens aqueous extract and the placebo for 30 days,the improvement rates of main clinical symptom and signs in the interventional group were 67.31% and 61.54%,while those in placebo group were 19.23% and 11.54%,with significant difference（P0.05）.Before the experiment,the integral of main clinical symptom and signs between the two groups did not show significant difference（P0.05）.But after 30 days,the integral of main clinical symptom and signs in the interventional group significantly decreased（P0.05）,compared with itself before the experiment and the placebo group.Conclusion Rabdosia rubescens aqueous extract is safe and effective for patients with chronic pharyngitis.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2011年第2期170-173,共4页
Journal of Central South University ：Medical Science
关键词
冬凌草水提物
安慰剂
慢性咽炎
双盲法
rabdosia rubescens aqueous extract
placebo
chronic pharyngitis
double-blind method
