摘要
腺相关病毒体是一种有DNA缺陷的非致病性细小病毒,重组腺相关病毒载体(rAAV)源于非致病的野生型腺相关病毒,具有安全性好、宿主范围广等优点。rAAV已成为基因治疗研究的热点,特别是在心血管疾病机制探讨和治疗研究中应用广泛。在过去几十年里,rAAV在高血压、心力衰竭、动脉硬化和心肌梗死等心血管疾病基因治疗中成果显著。
Adeno-associated virus is a kind of DNA defective parvovirus which is non-pathogenic.Recombinant-adeno-associated virus vector comes from wild-type non-pathogenic adeno-associated virus and is highly secure,and it also has the advantages of broad host range.Recombinant-adeno-associated virus vector has become a hot spot for gene therapy and is widely used in gene therapy for cardiovascular diseases,especially for hypertension,heart failure,arteriosclerosis,and myocardial infarction.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2011年第2期178-184,共7页
Journal of Central South University ：Medical Science
基金
supported by the National Natural Science Foundation of China(30873126)
the fund of Graduate Education Innovation Projeot(2009ssxt215)
关键词
重组腺相关病毒载体
心血管疾病
基因治疗
recombinant-adeno-associated virus vector
cardiovascular disease
gene therapy
