摘要
目的通过检测血清中总IgE(TIgE)、IgG、IgG4浓度在特应性皮炎(AD)发病过程中的变化,探讨健脾渗湿法治疗有效率与指标间的联系。方法选择38例AD患者为研究对象,于治疗前后观察其主要症状(包括瘙痒、睡眠、皮损面积、皮损严重程度),记录SCORAD积分,及检测血清中TIgE、IgG、IgG4水平。并将各项血清学指标与治疗有效率进行相关分析。结果治疗前的SCORAD评分为55.46±15.05,治疗后为49.41±12.33,两者有显著性差异(P<0.01);AD患者血清治疗前、后TIgE、IgG、IgG4均高于正常对照组(P<0.05)。但治疗后TIgE相对于治疗前明显下降,而IgG、IgG4水平明显升高。治疗有效率与TIgE、TIgE/IgG4治疗前后变化差值成中等正相关,相关系数分别为0.541,0.793。结论 TIgE、TIgE/IgG4水平变化是反映AD病情变化的重要指标,在一定程度上可用于评价病情是否好转。使用健脾渗湿法治疗AD后,TIgE、TIgE/IgG4随症状改善变化明显。
Objective To explore the biological significance of serum TIgE,IgG,IgG4 in atopic dermatitis（AD） patients.Methods Serum TIgE,IgG and IgG4 was measured in 38 atopic dermatitis patients and 15 health controls by immunofluorescence method.Main symptoms（such as pruritus degree,sleep state,skin destruction area,skin destruction serious degree） and the severe scoring of atopic dermatitis（SCORAD） index were collected before and after treatment respectively.Results The study showed that the mean levels of serum IgG4 and total IgE in 38 AD patients were（12.82±4.96）ug/L and（2175.16＋1982.80） U/ml respectively,which was significantly higher than the levels of healthy controls（P0.05）.But the levels of serum total IgE descend and IgG,IgG4 ascend after treatment.The results showed that TIgE,TIgE/IgG4 are positive correlation with the therapy availability and the related coefficient were 0.541 and 0.793 respectively.The levels of serum IgG,IgG4 and TIgE were significantly higher than the levels of healthy controls.It could be aiddiagnosis for AD.Conclusion The TIgE,TIgE/ IgG4 is the important indexs to react the change of patient＇s condition.It could be useful for evaluating the therapeutic effects.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2011年第1期20-22,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
关键词
特应性皮炎
血清总IGE
IgE/IgG4
SCORAD积分
atopic dermatitis
total immunoglobulin E
immunoglobulin E /immunoglobulin G4
severe scoring of atopic dermatitis
