重组人脑利钠肽对体外循环下心脏手术术后肾功能的影响被引量：4

The effects of recombinant human brain natriuretic peptide on postoperative renal function in patients undergoing cardiac surgery with cardiopulmonary bypass

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摘要目的探讨体外循环(CPB)下心脏手术围术期应用重组人脑利钠肽(rhBNP)对患者肾功能的影响。方法 33例行CPB下冠状动脉旁路移植术和瓣膜置换术患者随机分为观察组(A组,15例)与对照组(B组,18例)。A组为常规治疗基础上麻醉诱导后给予rhBNP治疗;B组为常规治疗。记录术前、术后0、8、24h血清肌酐(SCr)、肾小球滤过率(GFR);记录术前、术后N端脑钠肽原(NT-ProBNP)及尿量。结果术后24hB组Scr明显高于术前和A组,GFR明显低于术前和A组(P<0.05);术后B组NT-ProBNP明显高于术前和A组(P<0.05或P<0.01);术后24h尿量A组[(2275±145)ml]显著多于B组[(1927±267)ml](P<0.01)。结论 rhBNP能够改善CPB心脏手术患者术后早期肾功能。 Objective To determine the role of recombinant human brain natriuretic peptide （rhBNP） in postoperative renal function in patients undergoing cardiac surgery under cardiopulmonary bypass （CPB）. Methods .Thirty three patients undergoing coronary artery bypass grafting and valve surgery were randomly divided into one of two groups： the testing group （group A, n=15） and the control group （group B, n=18）. Group A received rhBNP for 24h after induction of anesthesia, but group B received conventional treatment. The 24 h levels of serum creatinine （SCr）, glomerular filtration rate （GFR）, N terminal pro-Brain natriuretic peptide （NT ProBNP）, and urine output were recorded. Results Compared with the preoperative contents, the 24 h levels of SCr,GFR and NT-ProBNP changed significantly（P〈0.05） ; the 24 h urine output in the group A [（2 275 ± 145） ml] was more than the group B [（1927 ± 267） ml] （P〈0.01）. Conclusion rhBNP can improve the early renal function of patients undergoing cardiac surgery.

作者吴金波王雁娟李明秋荣晓松

机构地区无锡市人民医院麻醉科

出处《临床麻醉学杂志》 CAS CSCD 北大核心 2011年第3期264-266,共3页 Journal of Clinical Anesthesiology

关键词重组人脑利钠肽心脏手术肾功能 Recombinant human brain natriuretic peptide Cardiac surgery Renal function

分类号 R654.2 [医药卫生—外科学]

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2易俊,景华,朱家全,董国华,许飚,罗立国,顾卫东.心脏瓣膜置换术后肾功能改变的临床分析[J].医学研究生学报,2006,19(7):603-606. 被引量：11

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