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TLR与足细胞损伤

TLR and Podocyte Injury
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摘要 TLRs（Toll—likereceptors）是一类重要的模式识别受体家族，主要调节灭然免疫反应。研究发现在。肾脏固有细胞及间质细胞都有TLR表达，其介导的炎性反应参与了许多肾脏疾病的发生。多种足细胞标志蛋白的发现加快了足细胞表面分子的研究进程。目前已发现足细胞表面有TLR的表达，且TLR的表达与足细胞的损伤有关。 TLRs are an important class of pattern recognition receptor family and the main regu- lator of innate immunity. It has been shown that both intrinsic renal cells and interstitial cells express TLRs. TLR-mediated inflammatory responses are involved in various renal diseases. The discovery of a variety of podocyte associated molecules has accelerated the finding of podocyte surface molecules, h has been found that podocyte express TLRs and mediate self-injury.
作者 何艳 张敏 姜华军 刘建社
机构地区 华中科技大学同济医学院附属协和医院肾内科
出处 《医学分子生物学杂志》 CAS CSCD 2011年第1期89-91,共3页 Journal of Medical Molecular Biology
基金 国家自然科学基金（No.30900682）
关键词 TOLL样受体 Toll-like receptors
分类号 R334.1 [医药卫生—人体生理学]
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参考文献12

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二级参考文献6

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医学分子生物学杂志
2011年 第1期

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