期刊文献+

标准化免疫治疗对哮喘儿童屋尘螨特异性IgG_4和肺功能的影响 被引量:8

Influence of specific immunotherapy on Dermatophagoides pteronyssinus-specific IgG_4 and pulmonary function in children suffering from allergic asthma
原文传递
导出
摘要 目的探讨标准化屋尘螨变应原制剂免疫治疗儿童哮喘,对其肺功能、气道反应性及血清屋尘螨特异性IgG4、血清屋尘螨特异性IgE的影响。方法选择31例轻-中度屋尘螨过敏性哮喘儿童,给予标准化屋尘螨变应原制剂治疗,疗程25周,检测治疗前后肺功能指标FEV1和PEF占预计值的百分比,PC20、血清屋尘螨特异性IgG4和屋尘螨特异性IgE水平。结果标准化特异性免疫治疗前后哮喘患儿肺功能FEV1和PEF占预计值的百分比分别为:治疗前(97.87±23.44)%、(99.95±29.52)%,治疗后(114.81±17.65)%、(116.51±19.52)%;治疗前后PC20值分别为(1.49±2.75)、(7.31±7.02)mg/ml;血清屋尘螨特异性IgG4水平治疗前为271.4 AU/ml(436.6 AU/ml)、治疗后为2 450.5 AU/ml(2 771.95 AU/ml);血清屋尘螨特异性IgE水平治疗前为87.14 AU/ml(70.26 AU/ml)、治疗后为100.00 AU/ml(59.25 AU/ml)。除了特异性IgE在治疗前后无显著变化(P>0.05)外,其余各项指标在治疗后均有显著上升(P<0.01)。结论特异性免疫治疗对变应性哮喘患儿的肺功能有明显的改善,血清屋尘螨特异性IgG4的升高在哮喘的免疫治疗中发挥了重要的保护作用。 Objective To explore the influence of specific Dermatophagoides pteronyssinus allergen preparation on pulmonary function,airway responsiveness,serum Dermatophagoides pteronyssinus-specific IgG4 and serum Dermatophagoides pteronyssinus-specific IgE of children suffering from allergic asthma.Methods Thirty-one children with mild-to-moderate dermatophagoides pteronyssinus allergic asthma were treated with specific immunotherapy using Dermatophagoides pteronyssinus allergen preparation for 25 weeks.The pulmonary function indexes,including percentages of FEV1 and PEF to their forecast values and PC20,as well as serum Dermatophagoides pteronyssinus-specific IgG4 level and serum Dermatophagoides pteronyssinus-specific IgE level were determined before and after the specific immunotherapy.Results After the specific immunotherapy,the percentages of FEV1 and PEF compared with their forecast values increased from(97.87±23.44)% and(99.95±29.52)% to(114.81±17.65)% and(116.51±19.52)%,respectively(P0.01).PC20 increased from 1.49±2.75 mg/ml to 7.31±7.02 mg/ml(P0.01).Serum Dermatophagoides pteronyssinus-specific IgG4 level and serum Dermatophagoides pteronyssinus-specific IgE level changed from 271.4 AU/ml(436.6 AU/ml) and 87.14 AU/ml(70.26 AU/ml) to 2 450.5 AU/ml(2 771.95 AU/ml) and 100.00 AU/ml(59.25 AU/ml),respectively,indicating insignificant difference of specific IgE level(P0.05) but significant increase of specific IgG4 level(P0.01).Conclusion Specific immunotherapy can significantly improve the pulmonary function of children suffering from allergic asthma.The increase of serum Dermatophagoides pteronyssinus-specific IgG4 plays an important role in immunotherapy of asthma.
出处 《第三军医大学学报》 CAS CSCD 北大核心 2011年第6期618-620,共3页 Journal of Third Military Medical University
基金 "十一五"国家科技支撑计划基金(2007BAI24B05) 重庆市自然科学基金(CSTC2007BB5320)~~
关键词 变应性哮喘 标准化特异性免疫治疗 肺功能 屋尘螨特异性IgG4 allergic asthma specific immunotherapy pulmonary function specific IgG4
  • 相关文献

参考文献13

  • 1Bousquet J, Lockey R, Malling H J. Allergen immunotherapy: thera- peutic'vaccines for allergic diseases. A WHO position paper[J]. J Allergy Clin Immunol, 1998, 102(4 Pt 1 ) : 558-562.
  • 2Pifferi M , Baldini G, Marrazzini G, et al. Benefits of immunotherapy with a standardized Dermatophagoides pteronyssinus extract in asthmatic children : a three-year prospective study [ J ]. Allergy, 2002, 57 ( 9 ) : 785 - 790.
  • 3王模奎,黄英,刘恩梅,陈坤华,戴继宏,蒋永惠,李芙蓉.重庆市5969例儿童哮喘常见变应原皮试临床分析[J].第三军医大学学报,2007,29(6):493-493. 被引量:9
  • 4儿童哮喘防治常规(试行)[J].中华儿科杂志,1998,36(12):747-751. 被引量:2372
  • 5王模奎,黄英,刘恩梅,戴继宏,陈坤华,蒋永惠,李素碧.标准化屋尘螨变应原制剂治疗儿童变应性哮喘68例[J].中国新药与临床杂志,2006,25(12):935-938. 被引量:17
  • 6Crapo R O, Casaburi R, Coates A L, et al. Guidelines for methaeholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999 [ J ]. Am J Respir Crit Care Med, 2000, 161 ( 1 ) : 309 - 329.
  • 7徐放明,潘伟,刘湘,文立凡,张玉华,高明亮,刘国平.哮喘患者支气管肺泡灌洗液螨特异性IgE、IgG_4测定临床意义研究[J].中国医师杂志,2000,2(9):532-534. 被引量:5
  • 8Pipet A, Botturi K, Pinot D, et al. Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacy[J]. Respir Med, 2009, 103(6) : 800-812.
  • 9张忠芳,何韶衡.变态反应疾病免疫治疗机制的研究进展[J].广东医学,2006,27(9):1410-1412. 被引量:7
  • 10van-Neerven R J, Knol E F, Ejrnaes A, et al. IgE,Mediated allergen presentation and blocking antibodies : regulation of T-cell activation in allergy [ J ]. Int Arch Allergy Immunol, 2006, 141 (2) : 119 - 129.

二级参考文献45

共引文献2461

同被引文献94

引证文献8

二级引证文献21

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部