摘要
目的：探讨血小板分布宽度（Platelet distribution width,PDW）作为血小板活化指标的可行性研究。方法：应用Sysmex XE-2100全自动血细胞分析仪测定100份本院体检的25~40周岁正常人群和100名已确诊的血小板活化患者的血常规标本的平均血小板体积（Mean platelet volume,MPV）与PDW值。随机选取本院患者血常规标本100份,在采血后的1、2、3、4 h检测MPV与PDW值。结果：已确诊的血小板活化患者的MPV与PDW值均显著高于正常人群MPV与PDW值（P〈0.001）。血样本采集后的12、、3、4h时的MPV值升高,但PDW值均值逐渐降低。采血后4h的MPV值明显高于采血后1h的MPV检测值（P〈0.05）,但4 h时的PDW值明显低于1 h时的PDW检测值（P〈0.01）。结论：MPV与PDW检测简单,在血小板活化时显著增高。血小板发生储存损伤时,PDW值却降低,故PDW是比较特异的血小板活化指标。
Objective： To evaluate the feasibility of platelet distribution width（PDW） for platelet activation.Methods： Mean platelet volume（MPV） and PDW in three groups of persons,using Sysmex XE-2100 hematology analyzer,were measured.The first group were healthy control subjects.The second study group were patients with established platelet activation.The third group were randomly chosen patients,whose MPV and PDW were assessed based on the effect of storage time.Results： There was a significant increase in MPV and PDW in patients with established platelet activation compared with healthy control subjects（P0.001）.A significant increase was observed in MPV（P0.05）,but decrease in PDW over storage time（P0.01）.Conclusion： PDW is a more specific marker of platelet activation than MPV is,and the detection method with PDW is simple and accurate.PDW increases obviously during platelet activation,whereas it decreases during simple platelet swelling over storage time.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2011年第2期200-202,共3页
Journal of Chongqing Medical University
关键词
血小板分布宽度
血小板活化
platelet distribution width
platelet activation
