摘要
目的初步了解浙江省宁波地区流动人口结核病耐药状况,为制定流动人口结核病控制策略提供依据。方法将宁波地区2007-2009年进行耐药监测的新发及复治痰培养阳性肺结核病例作为研究对象,并对所有分离培养阳性菌株进行菌型鉴定及利福平(R)、异烟肼(H)、链霉素(S)、乙胺丁醇(E)4种一线药物敏感性测试,分析流动人口耐药结核病流行状况。结果共纳入659例培养阳性肺结核病例,其中结核分枝杆菌565例,占85.7%,非结核分枝杆菌94例,占14.3%;流动人口肺结核患者的总耐药率为33.5%(189/565),耐多药率为6.4%(36/565);新发患者的耐药率为29.5%(149/505),耐多药率为4.4%(22/505);复治患者的耐药率为61.7%(37/60),耐多药率为23.4%(14/60)。结论宁波地区流动人口的结核病耐药率较高,须针对流动人口特点加强防治工作。
Objective To investigae drug resistance of Mycobacterium tuberculosis among floating population in Ningbo. Methods All sputum culture positive patients among migrant population confirmed in district tuberculosis dispensaries in Ningbo from 2007 to 2009 were enrolled.The drug susecptibility tests of inoniazid,rifampicin,streptomycin,and ethambutol were performed with proportion method. Results Among all patients enrolled,659 had positive bacterial culture and drug susceptibility results.Of the 659 strains,565 strains were Mycobacterium tuberculosis and 94 strains were Mycobacterium non-tuberculosis.The total frequency of drug resistance was 33.5%（189/565）;the total frequency of multi-drug resistance was 6.4%（36/565）.The initial drug resistance rate was 29.5%（149/505） and the initial multi-drug resistance rate was 4.4%（22/505）.The acquired drug resistance rate was 61.7%（37/60） and the acquired multi-drug resistance rate was 23.4%（14/60）. Conclusion The prevalence of drug-resistant tuberculosis among floating population was relatively high in Ningbo suggesting the necessity to strengthen the tuberculosis control program among migrant population.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2011年第4期394-395,共2页
Chinese Journal of Public Health
关键词
肺结核
耐药性
流动人口
pulmonary tuberculosis
drug-resistance
floating population
