摘要
目的：观察体外循环（ＣＰＢ）病人术中持续吸入一氧化氮（ＮＯ）对术后出血和肺功能的影响。 方法：４２例病人被分为对照组（ｎ＝ ２１）和一氧化氮（ＮＯ）组（ｎ＝ ２１）。ＮＯ组，通过肺和氧合器（ＣＰＢ中）吸入浓度为４０ ｐｐｍ （１ ｐｐｍ ＝ １／１０６）的ＮＯ。回顾性查阅所有病人的术后胸腔和纵隔引流量、术后血红蛋白含量、血小板和白细胞计数、肺泡—动脉血氧分压差及胸肺顺应性（Ｃｄｙｎ ）等。 结果：ＮＯ组与对照组比较术后１２小时和２４ 小时的胸腔和纵隔引流量分别减少４４％ 和３４％ ，术后４～１０ 小时和１０～２０小时的血小板计数分别增加了２２％ 和２１％ ，术后０～１小时和１～４ 小时病人的肺泡—动脉血氧分压差分别减少了３３％ 和２６％ 。 结论：体外循环术中持续吸入浓度为４０ ｐｐｍ 的ＮＯ可减少术后出血和改善术后肺功能。
Objective:To find the effect of continuous nitric oxide (NO) inhalation on the postoperative bleeding and lung function in patients with extracorporeal bypass(CPB). Methods:Forty two patients were divided into control group and NO inhalation group(each group n =21).In NO group,40 ppm NO was inhaled through the lung and oxygenator(during CPB).The postoperative drainage,the counts of platelet and leukocyte,the P (A-a) O 2 of lung and compliance of lung and thorax(C dyn ) were studied retrospectively. Results:The postoperative drainage was reduced by 44% and 34% at 12 hours and 24 hours in NO group postoperatively.The counts of platelet was increased by 22% and 21% at 4～10 hours and 10～20 hours after operation in NO group.The P (A-a) O 2 of lung was reduced by 33% and 26% at 0～1 hours and 1～4 hours in NO group postoperatively. Conclusions:In patients with extracorporeal bypass,continuous NO inhalation can reduce postoperative bleeding and improve the postoperative lung function.
出处
《中国循环杂志》
CSCD
北大核心
1999年第4期239-241,共3页
Chinese Circulation Journal
基金
国家自然科学基金
青年基金
关键词
一氧化氮
体外循环
术后
肺功能
Nitric oxide
Extracorporeal bypass
Postoperative lung function
