摘要
目的分析惠州市人狂犬病疫苗暴露后免疫的抗体水平,及时了解和观察本市犬咬伤人群接种狂犬病疫苗后(IgG)抗体产生的免疫效果,评价目前本市使用的狂犬病疫苗质量,为今后的狂犬病疫苗预防接种工作及制订科学完善的防患措施提供科学依据。方法惠州市人狂犬病疫苗暴露后(咬伤后),抽取全程接种五针疫苗1个月后自愿进行狂犬病毒抗体检测人员静脉血,按酶联免疫法检测抗狂犬病毒抗体。结果惠州市1186例接种狂犬疫苗后抗狂犬病毒抗体水平检测阳性率为96.1%。其中男性97.2%,女性94.5%。不同年龄组抗狂犬病毒抗体阳性率有随着年龄的增长而呈下降的趋势。不同厂家狂犬疫苗免疫效果相当,差异无统计学意义。结论通过0、3、7、14和28d全程接种狂犬疫苗后,96.1%以上的患者抗狂犬病毒抗体水平合格,还有3.9%的患者抗体水平低于保护阈值,需进一步加强接种。
Objective To analyze the antibody level to rabies virus in people received vaccination after exposure in Huizhou,understand the immunization effect in time,evaluate the quality of the rabies vaccine in use and provide evidence for the improvement of rabies vaccination.Methods The detection of rabies virus antibody was conducted in people who were fully vaccinated（5 times） after exposure by ELISA one month latter.Results The positive rate of rabies virus antibody in 1 186 vaccinees was 96.1%（97.2% in males and 94.5% in females）.The positive rate was lower in higher age groups.The immunization effect was similar among the vaccines from different manufactures,the difference had no statistical significance.Conclusion Fully vaccination against rabies at 0,3,7,l4,28 day made more than 96.1% of the vaccinees to have qualified antibody level,only 3.9 %were with antibody level lower than protective threshold.The vaccination should be further strengthened.
出处
《预防医学情报杂志》
CAS
2011年第4期303-305,共3页
Journal of Preventive Medicine Information
