摘要
目的探讨甲亢131I疗后促甲状腺激素受体抗体(TRAb)变化规律与预后的关系。方法收集经131I治疗的甲亢(Graves病)患者317例,分别于131I治疗前、后3、6、9、12等月监测血清FT3、FT4、sTSH、TRAb等。按131I治疗前后TRAb升降变化规律分为八组。预后分为未愈(无效+好转)、痊愈、甲减。结果 131I治疗前后TRAb保持阴性不变组疗效最好,TRAb阳性疗后先降后升组疗效最差。131I疗前TRAb阴性各组较阳性各组疗效好。131I疗前TRAb阳性,疗后不变、升高或先降后升组较疗后降低组疗效较差。结论 131I治疗前后TRAb升降变化规律可以较好地反映预后,对治疗有一定指导意义。
Objective To discuss the change rule of TRAb and the correlation with prognosis in patients with Graves＇ disease before and aftermI treatment. Methods To collect 317 patients with Graves＇ disease treated with 231I , and measure the serum FT3 , FT4, sTSH, TRAb Etc at 0 and 3,6,9,12 months alter treated withTM I . All the patients were divided based on the change rule of TRAb into eight groups. The prognosis include uncured （ inefficacy and mend）, cured and hypothyroidism. Results Of all the groups, the group with TRAb negative always was the best, and the group with TRAb positive down then up after 131I treatment was the worst on the prognosis. The prognosis of the groups with TRAb negative before 13＇I treatment was better than that of the groups with TRAb positive. It was worse the prognosis of the groups with TRAb positive before and after treatment, or increased or decreased then increased. Conclusion The change rule of TRAb before and afterTM I treatment could reflect better prognosis, and was valuable forl31I treatment.
出处
《中国辐射卫生》
2011年第1期39-40,共2页
Chinese Journal of Radiological Health
