摘要
目的 研究脐血移植（ ＵＣＢＴ） 对恶性血液病的根治性治疗； 观察其长期造血重建和移植物抗宿主病（ＧＶＨＤ） 及移植并发症发生情况。方法 给１ 例急性粒细胞白血病完全缓解期的１１ 岁男性患儿移植ＨＬＡ 配型相合的同胞脐血。预处理选用ＢＵ／ＣＹ 方案（ 马利兰４ ｍ ｇ ·ｋｇ －１ ·ｄ － １ ×４ ，环磷酰胺６０ ｍｇ ·ｋｇ － １ ·ｄ － １ ×２） 。ＧＶＨＤ 预防用环孢霉素Ａ（ＣｓＡ） 。移植有核细胞为０ ．３５ ×１０８／ｋｇ ，ＣＦＵＧＭ １ ．８２ ×１０４／ｋｇ ，ＣＤ３４ ＋ 细胞２ ．０４ ×１０５／ｋｇ 。结果 ＋ １４ 天骨髓显示造血重建；＋ ２１ 天中性粒细胞（ＡＮＣ） ＞ １ ．０ ×１０９／Ｌ；＋ ６０ 天ＤＮＡ 位点检测显示移植物植入成功；＋ １００ 天受者血型由Ｏ 型转为供者血型Ｂ 型。随访３３０ 天，患者情况正常，未发生急、慢性ＧＶＨＤ。结论本例为国内首例异基因脐血移植治疗急性粒细胞白血病获得成功；开展同胞ＨＬＡ 相合脐血移植安全、有效，适合中国国情，值得深入研究。
Objective To apply umbilical cord blood stem cell transplantation (UCBSCT) to the treatment of hematological malignancies, and to observe the persistent hematopoietic reconstitution, graft versus host disease (GVHD) and transplantation related complications. Methods An 11 year old patient with acute myeloid leukemia in complete remission (CR) received UCBSCT from a HLA compatible sibling. The conditioning regimen was BU/CY (busulfan 4 mg·kg-1·d-1×4,cyclophosphamide 60 mg·kg-1·d-1×2). CsA was given for prophylaxis of acute GVHD. The patient received 0.35×108 nucleated cells/kg, including 1.82×104 CFU GM/kg and 2.04×105 CD34+cells/kg. Results The recipient showed hematopoietic reconstitution on day 14 post transplantation;ANC>1.0×109/L on day 21; DNA fingerprinting showed engraftment on day 60, the blood type of the patient changed from O group to B group. In the follow up of 330 days, the patient was in good condition without acute or chronic GVHD. Conclusion It is the first case reported in China that have succeeded in the treatment of acute myeloid leukemia by allogeneic UCBSCT.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1999年第8期399-401,共3页
Chinese Journal of Hematology
关键词
造血干细胞移植
白血病
脐血移植
HLA
Stem cell transplantation,umbilical cord blood Leukemia, myeloid,acute
