摘要
从１５００名孕妇中筛查出８２名ＨＢｓＡｇ≥１∶６４滴度的阳性携带者的新生儿，按随机、双盲、设安慰剂的原则将研究对象分为疫苗组和对照组（人数比为３∶１）。疫苗组在新生儿出生２４小时内注射第１针，１月、６月龄分别注射第２针、第３针乙肝疫苗，对照组按同样程序注射安慰剂。在第１３年时抗ＨＢｓ阳性率仍高达５９３２％（３５／５９）；对照组１３年来有２３５３％（４／１７）受到自然感染后变为抗ＨＢｓ阳性，疫苗组与对照组有显著性差异（Ｐ＜００５）。疫苗组的抗ＨＢｓ阳性者中，抗ＨＢｓＧＭＴ峰值在第１２个月，Ｓ／Ｎ值为６８８４，到１３年时已下降到１７８２。相当于高峰的１／４，但仍明显高于对照组。除出生时疫苗组与对照组ＨＢｓＡｇ阳性率无明显差异外，疫苗组ＨＢｓＡｇ阳性率一直明显低于对照组，在第１３年时疫苗组和对照组的ＨＢｓＡｇ阳性率分别为１８６４％、４７０６％，有显著性差异（Ｐ＜００５）。
infants who were born by HBV carrier mothers were dividedintotwo groups accrding to randomized,placebo controlled method,onewasvaccine group and antother was controlled group(proprotion of numberwas 3∶1).The three doses of hepatitis B vaccine were injected oninfantswhich were in vaccine group within 24 hours after born,first month and 6the month.It was the same in controlled group but vaccine wasreplace by placbo.The rate of anti HBs Positive in vaccine group was the peak(67.8% 40/59) on 12th month,then it come to decline slowly to (59.32%(35/59) on 13th years.There are 23 53%(4/17) subjects become anti HBspositive in controlled group by natural infection.The differencebetweer the groups are significance during the studying time.On the contrary with anti HBs,the rates of HBsAg Havebeing lower in vaccine group than controlled group during the time.They were 18.64% in vaccine group and 47.06% in controlled grouptespectively on 13th year(P<0 05).
出处
《中国公共卫生》
CAS
CSCD
北大核心
1999年第8期693-694,共2页
Chinese Journal of Public Health
基金
河南省科委基金
关键词
乙肝疫苗
母婴阻断
乙型肝炎
垂直传播
Supported by the Youth Natrual Scientific Foundatiion of Henan Province,No.9712003000
