摘要
目的了解医院2007-2009年铜绿假单胞菌的分离情况及耐药性变化趋势,指导临床合理使用抗菌药物。方法回顾性调查医院2007年1月-2009年12月从临床分离的1163株铜绿假单胞菌,对17种常规抗菌药物的耐药结果,并进行统计分析。结果该菌连续3年对阿米卡星的耐药率最低,为8.2%~11.7%,耐药率最高的为头孢唑肟,连续3年均〉70.0%;替卡西林、头孢曲松、头孢噻肟、磺胺甲噁唑/甲氧苄啶等药物的耐药率3年均〉30.0%;对包括第三代和第四代头孢菌素类、β-内酰胺酶抑制剂、氟喹诺酮类、碳青霉烯类、磺胺类、氨曲南在内的9种抗菌药物的耐药率均有显著下降（P〈0.05）,对其他抗菌药物的耐药率无明显变化（P〉0.05）。结论医院强力推行的某些措施可能在一定程度上遏制了铜绿假单胞菌的耐药上升趋势。
OBJECTIVE To explore the resistance of Pseudomonas aeruginosa（PAE） isolated from 2007-2009 in our hospital and provide the guidance for the clinical treatment.METHODS Retrospective survey of 1163 strains of PAE from Jan 2007 to Dec 2009 and the drug resistance to 17 common-used antibiotics were statistically analyzed.RESULTS The resistance rate of PAE to amikacin was the lowest,accounting for 8.2%-11.7%,and to ceftizoxime was the highest（more than 70.0%）;to ticarcillin,ceftriaxone,cefotaxime and SMZ-TMP,and so on were all more than 30.0% in 3 years.Drug resistance rates to those antibiotics,including 3rd and 4th generation cephalosporins,βlactamaseinhibitor,FQNS,carbapenem,sulfanilamide group and aztreonam,decreased significantly（P0.05）.The resistance rate to other antibiotics did not change significantly（P0.05）.CONCLUSION Some measures pursued by the hospital maybe curb the upward trend of the drug resistance about PAE.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第7期1437-1439,共3页
Chinese Journal of Nosocomiology
关键词
铜绿假单胞菌
抗菌药物
耐药性
Pseudomonas aeruginosa
Antibiotics
Drug resistance
