摘要
目的:通过动物实验观察牛蒡水提液对高脂模型大鼠和正常大鼠血脂的调节作用。方法:制备牛蒡水提液后分别给高脂模型大鼠和正常大鼠灌胃,灌胃剂量为相当于人9克生药/60kg体重,检测灌胃前后大鼠血脂水平进行比较。结果:牛蒡水提液对高血脂大鼠和正常大鼠都具有降血脂作用,正常饮食组大鼠血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)分别由1.60±0.20(单位为mmol/L,下同)、0.62±0.16、1.04±0.15、0.95±0.11下降到1.29±0.14、0.49±0.12、0.82±0.14、0.76±0.09;造模后继续高脂饮食喂养组分别由5.08±2.22、1.40±0.39、1.85±0.61、2.04±1.18下降到3.70±2.17、0.94±0.37、1.01±0.59、1.21±1.14;造模后停止高脂饮食喂养组分别由1.85±1.70、0.62±0.13、0.98±0.09、0.92±0.09下降到1.38±1.45、0.46±0.18、0.85±0.12、0.83±0.09。但牛蒡对于高密度脂蛋白和低密度脂蛋白没有选择作用。结论:牛蒡水提液具有明显的调节血脂作用,具有广阔的开发应用前景。
Objective：To observe the regulating effect of waterextract of burdock on serum lipids in hyperlipidemia model rats and normal rats.Methods：Hyperlipidemia model rats and normal rats were respectively given 9g/60kg body weight waterextract of burdock by gavage administration.The levels of serum lipids were detected before and after the gavage administration.Results：Waterextract of burdock showed effects of lowering blood lipids on three groups of rats.In control group serum TC,TG,HDL and LDL declined respectively from 1.60±0.20（mmol/L）,0.62±0.16（mmol/L）,1.04±0.15（mmol/L）,0.95±0.11（mmol/L）to 1.29±0.14（mmol/L）,0.49±0.12（mmol/L）,0.82±0.14（mmol/L）,0.76±0.09（mmol/L）,serum indexes of rats with persistent high fat diet declined respectively from 5.08±2.22（mmol/L）,1.40±0.39（mmol/L）,1.85±0.61（mmol/L）,2.04±1.18（mmol/L）to 3.70±2.17（mmol/L）,0.94±0.37（mmol/L）,1.01±0.59（mmol/L）,1.21±1.14（mmol/L）,while serum indexes of rats with stoping high fat diet after hyperlipidemia model declined respectively from 1.85±1.70（mmol/L）,0.62±0.13（mmol/L）,0.98±0.09（mmol/L）,0.92±0.09（mmol/L） to 1.38±1.45（mmol/L）,0.46±0.18,（mmol/L）0.85±0.12（mmol/L）,0.83±0.09（mmol/L）.there are no effects on HDL and LDL.Conclusion：Waterextract of burdock shows obvious effect of regulating serum lipids,so there is a hopeful prospect for the application and exploration of burdock products.
出处
《中华中医药学刊》
CAS
2011年第4期854-856,共3页
Chinese Archives of Traditional Chinese Medicine
基金
泰安市科技局大学生创新计划资助项目(2009D1026)
关键词
牛蒡水提液
血脂
三酰甘油
总胆固醇
waterextract of burdock
serum lipids
triacylglycerol
cholesterol
