摘要
目的观察奥沙利铂联合希罗达治疗晚期胃癌的疗效及毒副作用。方法 L-OHP 130 mg/m2,加入5%GS 500ml中静脉滴注2 h,第1 d,Xeloda 1 000 mg/m2,2次/d,口服,第1~14 d,21 d为1周期,连用2个周期后评价疗效。结果 CR1例,PR 12例,SD 8例,PD 8例,有效率为44.8%;中位疾病进展时间为7.2个月,中位生存期达到10.1个月。主要毒性反应为外周感觉神经异常、骨髓抑制、手足综合征、恶心和呕吐,患者均可以耐受。结论奥沙利铂联合希罗达方案治疗晚期胃癌疗效较好,毒副反应可以耐受,值得深入研究。
Objective To evaluate the efficacy and toxicity of Oxaliplatin combined with Xeloda（XELOX） in the treatment of advanced gastric cancer.Methods 29 patients with advanced gastric cancer received intravenous infusion of Oxaliplatin at the dose of 130 mg/m2 on day 1,and oral administration of Xeloda at1 000 mg/m2 twice a day on days 1~14.The chemotherapy was repeated every 21 days and the efficacy was evaluated after 2 cycles.Results The overall response rate was 44.8%（13/29）.One of 29 patients achieved a complete response,and 12 had partial responses.Stable disease was observed in 8 patients and progressive disease in 8.The median time to progression and overall survival was 7.2 months and 10.1 months.The major toxic effects were peripheral neuritis,myelosuppression,hand-foot syndrome,nausea and vomiting,but they were acceptable.Conclusion Oxaliplatin combined with Xeloda regimen is effective in the treatment of patients with advanced gastric cancer,and its toxicity is tolerable,which needs further study in clinical practices.
出处
《安徽医学》
2011年第3期283-285,共3页
Anhui Medical Journal
关键词
胃肿瘤
奥沙利铂
希罗达
药物疗法
Stomach neoplasms
Oxaliplatin
Xeloda
Drug therapy
