摘要
目的 研究 Ｃ Ｄ４ ４ 和ｎ ｍ ２ ３ 在肾脏肿瘤中表达情况。 方法 采用免疫组化 Ｌ Ｓ Ａ Ｂ 法对１０ 例肾脏良性肿瘤，３８ 例肾脏恶性肿瘤及６ 例转移淋巴结中的 Ｃ Ｄ４ ４ 和ｎｍ ２３ 表达情况进行检测，并进行临床随访。 结果 Ｃ Ｄ４ ４ 在肾恶性肿瘤中表达阳性率显著高于肾良性肿瘤，且高分期肿瘤阳性率显著高于低分期肿瘤。ｎ ｍ２３ 在肾脏良、恶性肿瘤间表达无差别，亦与分期无关，但在有转移的肾癌中均呈阴性表达。随访２ 年，ｎｍ ２３ 、 Ｃ Ｄ４ ４ 不能单独判断预后，但 Ｃ Ｄ４ ４ 阳性、ｎ ｍ２３ 阴性的肾癌预后较差。 结论 Ｃ Ｄ４ ４ 在肾脏恶性肿瘤的发生、浸润中发挥作用，ｎｍ ２３ 对限制肿瘤的转移有一定的影响。 Ｃ Ｄ４ ４ 和ｎ ｍ２３ 联合检测，可作为判断肾癌的预后指标。
Objective To investigate and evaluate the expressions of C D4 4 and n m23 in human renaltu mors. Methods C D4 4 and n m23 expressions were assayed by means of im m unohistochemical L S A Btechnique in 10 cases of benign renal tu mors ,38 malignantrenaltum ors and in 6 cases oflym ph nodes withmetastasis . Results C D4 4 expression was significantly higher in the malignant renal tu mors than the be nign ones and was significantly higherin the high stage tu mors. There was no significant difference of nm 23expression between the benign and the m alignant renaltum ors and n m23 expression was not relevantto thestage of malignant tu mors . However ,nm 23 has been always negativein cases of renalcarcino ma with metas tasis. The patients have been follo wed up for 2 years . Conclusions Neither C D4 4 nor n m23 expressionalone could serve as a prognostic marker . Ho wever,in case C D4 4 was positive and n m23 negative the progno sis would be poor . C D4 4 might beinvolved in the development and invasion of malignant renaltum ors whilenm 23 might play a rolein therestriction of m etastasis . Co mbined assay of C D4 4 and nm 23 expressions mightserve as a prognostic marker of m alignant renal tu mors .
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1999年第9期551-553,共3页
Chinese Journal of Urology
