摘要
目的:了解女性卵泡刺激素(follicle stimulating hormone,FSH)水平与骨代谢密切相关的几种细胞因子之间的关系。方法:测量703例年龄为20～80岁健康女性的血清FSH、护骨素(osteoprotegerin,OPG)、瘦素(leptin)、转化生长因子(transforming growth factor,TGF)β1和β2,并分析它们之间的关系。结果:血清FSH与OPG(r=0.447,P<0.01)和TGF-β2(r=0.344,P=<0.01)呈正相关,与TGF-β1呈负相关(r=-0.374,P<0.01);经年龄调整后血清FSH与瘦素呈负相关(r=-0.265,P<0.01)。多元线性回归分析显示,FSH对TGF-β1是一个负性决定因素,其决定性作用最大为22.6%;FSH对OPG和TGF-β2是一个正性决定因素,其决定性作用分别为9.9%和1.1%。FSH对瘦素几乎无影响。结论:女性年龄相关的FSH水平与血液中细胞因子TGF-β1,OPG和TGF-β2的变化有关。
Objective To determine the relation between follicle-stimulating hormone （FSH） level and bone metabolism-related cytokines in women. Methods A cross-sectional study of 703 healthy Chinese women, aged 20-80 years, was conducted. Serum FSH, osteoprotegerin （OPG）, leptin, transforming growth factor-beta 1 （TGF-β1）, and transforming growth factor-beta 2 （TGF-β2） were detected.Results Serum FSH was positively correlated with OPG （r=0.447, P0.01） and TGF-β2 （r=0.344, P0.01）, and negatively correlated with TGF-β1 （r=-0.374, P0.01）. After adjustment of age, a negative correlation was found between FSH and leptin （r=-0.265, P0.01）. The multiple linear stepwise regression analysis showed that serum FSH was a negative determinant factor of TGF-β1, and 22.6% changes in TGF-β1 was determined by FSH. FSH was, however, a positive determinant factor of OPG and TGF-β2, and 9.9% and 1.1% of the effect on OPG and TGF-β2 was performed by FSH, respectively. Serum FSH almost had no effect on leptin. Conclusion Serum FSH level in adult women is related to bone metabolism-related cytokines, such as TGF-β1, OPG, and TGF-β2.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2010年第12期1266-1271,共6页
Journal of Central South University ：Medical Science
