摘要
目的评价半纤维素单纯闭合性敷料Veloderm促进烧伤整形手术刃厚供皮区创面愈合的有效性和安全性。方法采用随机、开放、阳性药平行对照的试验方法进行研究。将Veloderm外敷于首次烧伤或整形手术刃厚供皮区创面(试验组,n=24),以临床常用且疗效确定的凡士林油纱布作为阳性药平行对照(对照组,n=24),比较两组创面愈合时间以及手术后第7天的创面愈合百分率、累计痊愈率及总有效率,观察不良反应的发生情况,评价Veloderm对创面愈合的促进作用以及使用的安全性。结果试验组和对照组创面愈合时间分别为(6.25±1.11)d和(7.00±0.93)d,两组间差异有统计学意义(P<0.05)。术后第7天,试验组创面愈合百分率、累计痊愈率和总有效率分别为(97.92±5.69)%、87.50%和100%,显著高于对照组的(93.37±8.92)%、58.33%和83.33%,差异均有统计学意义(P<0.05)。两组均无药物相关不良反应发生病例。结论纤维素单纯闭合性敷料Veloderm外敷对烧伤或整形手术供皮区创面的愈合具有显著促进作用,且使用安全性良好。
Objective To investigate the efficacy and safety of hemicellulose dressing Veloderm for wound healing of donor sites of burn or reconstruction. Methods A randomized,open and controlled clinical trial was conducted.Hemicellulose dressing Veloderm（test group,n=24） and commonly used Vaseline gauze（positive parallel control）（control group,n=24） were applied to the donor sites of burn or reconstruction,respectively.The time of wound healing,and wound healing rates,cumulative healing rates and total effective rates 7 d after operation were compared between two groups,the adverse effects were observed,and the efficacy and safety of Veloderm for wound healing were evaluated. Results There was significant difference in the healing time of donor sites between test group and control group [（6.25±1.11） d vs（7.00±0.93）d,P〈0.05].The wound healing rate,cumulative healing rate and total effective rate 7 d after operation in test group were significantly higher than those in control group [（97.92±5.69）% vs（93.37±8.92）%,87.50% vs 58.33%,100% vs 83.33%;P〈0.05 for all].There was no medicine-related adverse effect in both groups. Conclusion Hemicellulose dressing Veloderm is effective and safe for wound healing of donor sites of burn or reconstruction.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第12期1535-1539,共5页
Journal of Shanghai Jiao tong University:Medical Science
