摘要
目的:了解中国外阴阴道假丝酵母菌病(VVC)的致病菌种,并对影响VVC严重程度的相关因素进行研究。方法:采用多中心开放性大样本研究,对416例VVC进行流行病学情况调查,并进行真菌培养,鉴定菌种。结果:①416例患者中重度VVC311例,非重度VVC105例。培养共获得菌株365株,重度VVC菌种298株,分布为白假丝酵母菌276例(92.6%);非白假丝酵母菌22例(7.4%),包括热带假丝酵母菌5例(1.7%),克柔假丝酵母菌2例(0.7%),光滑假丝酵母菌4例(1.3%),近平滑假丝酵母菌3例(1.0%)及其他酵母菌8例(2.7%)。单纯VVC67例,白假丝酵母菌54例(80.6%)。②VVC严重程度与患者吸烟之间存在显著的相关性,相关系数为0.104(P<0.05);患者的性伴侣个数与疾病严重程度的相关系数为0.103(P<0.05),表明患者的性伴侣个数越多,病情具有加重的趋势;患者清洗外阴的频率与患者的疾病严重程度存在显著正相关,相关系数为0.103(P<0.05);最近12个月外阴阴道假丝酵母菌病的发作次数与患者的疾病严重程度成正相关,相关系数为0.162(P<0.05),表明复发患者的疾病较为严重。结论:①白假丝酵母菌为重度VVC的主要致病菌。②VVC患者的不良生活习惯在对疾病的严重程度有重要影响。
Objective：To study the pathogenic fungal population of vulvovaginal candidiasis（VVC） and the related factors of severity of VVC. Methods：A multi-center open large scale study of 416 cases of VVC was performed and vaginal fungal population was identified by fungal culture. Results：①Severe VVC （SVVC） patients were identified in 311 out of the 416 subjects,non-severe VVC patients were 105 cases. 365 fungal populations were found,among them 298 populations were found in SVVC. The distribution was 276 cases of candida albicans（92.6%）,22 cases of non candida albicans（7.4%）,which including 5 cases of candida tropicalis（1.7%）,2 cases of candida krusei strains（0.7%）,4 cases of candida glabrata（1.3%）,3 cases of candida parapsilosis（1.0%）,and other yeasts （2.7%）. For the 67 cases of simple VVC,candida albicans accounted for 80.6% （54 cases）. ②The severity of VVC was related with the following factors：smoking （r= 0.104,P〈0.05）,number of sexual partners（r=0.103,P〈0.05）,the frequency of washing vulva area （r=0.103,P〈0.05）,the relaps frequency of vulvovaginal candidiasis within the last 12 months（r=0.162,P〈0.05）. Conclusions：①Candida albicans is the predominant pathogen isolated from SVVC;②Unhealthy living habits play an important role in the severity of VVC.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2010年第12期906-909,共4页
Journal of Practical Obstetrics and Gynecology
