摘要
目的观察三氧疗法配合柳氮磺吡啶经结肠途径治疗轻、中度远段溃疡性结肠炎的效果。方法采用前瞻性随机对照试验,将符合入选标准的活动期轻、中度远段溃疡性结肠炎患者分成三氧加结疗组、结疗组及对照组各18例。3组均予柳氮磺吡啶2g/d,三氧加结疗组和结疗组经结疗机途径给药,三氧加结疗组加用三氧,对照组经灌肠途径给药。临床观察期4周,分别于第0、2、4周复查大肠镜,进行疾病活动度评价,第0、4周取活检进行组织学评价。结果三氧加结疗组临床症状缓解速度,以及组织学分级下降程度均优于单纯柳氮磺吡啶结疗和灌肠治疗组,治疗过程中无一例发生不良反应。结论三氧疗法经结肠途径治疗溃疡性结肠炎是可行,值得进一步研究。
Objective To assess the therapeutic effect of ozone therapy combined with sulfasalazine sulfasalazine delivered via a colon therapy system in the treatment of distal ulcerative colitis. Methods This prospective randomized controlled clinical trial involved 54 patients with mild to moderate active distal ulcerative colitis,who were randomize into 3 groups in accordance with the inclusion criteria （n=18）. Each group was given sulfasalazine at the daily dose of 2 g,and in colon therapy group and ozone therapy plus sulfasalazine therapy group,sulfasalazine was delivered via a colon therapy system on a daily basis; the control group received sulfasalazine via retention enema only. At 0,2,and 4 weeks of the treatment,colonoscopy was performed to evaluate the disease activity,and biopsy samples were obtained at 0 and 4 weeks for histological examination. Results In comparison with colon therapy group and control group,ozone therapy plus colon therapy resulted in more rapid alleviation of the clinical symptoms and better histological improvement without any adverse effects. Conclusion Ozone therapy combined with sulfasalazine delivered via a colon therapy system is feasible and effective for treatment of ulcerative colitis.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2010年第12期2683-2685,共3页
Journal of Southern Medical University
基金
广西省科技厅计划项目(Z2009400)
