摘要
目的探讨同期放化疗对晚期食管癌侵及气管的临床疗效。方法收集经病理检查确诊的168例食管癌侵及气管病例,其中73例采取单纯放射治疗(单放组),以6/15MVX线常规外照射,1.8Gy/次,5次/周,照射总剂量61.2～64.8Gy;95例患者行化放疗治疗(化放组),予顺铂(DDP)联合氟尿嘧啶(5-FU)方案化疗(DDP20mgd1～d5,5-FU500mg/m2d1～d5)4个周期,28天为1周期,于第2周期化疗开始时行同期放疗,放疗方案同单放组。观察两组的近期疗效、毒副反应和远期疗效。结果化放组的有效率(RR)为65.3%,高于单放组的45.2%(P=0.009);化放组较单放组KPS评分提高更显著(P=0.004)。化放组的3年生存率为17.9%,高于单放组的6.9%(P=0.035)。两组主要毒副反应包括急性放射性食管炎、放射性气管炎和白细胞减少,化放组的白细胞减少发生率高于单放组(P=0.022)。结论同期放化疗对晚期食管癌侵及气管患者较单纯放射治疗的近期疗效好,明显改善患者的生活质量,生存时间延长,且相对安全。
Objective To evaluate the effects of chemoradiotherapy for esophageal cancer patients invading trachea or main bronchus.Methods One hundred and sixty-eight esophageal cancer patients invading trachea or main bronchus were diagnosed by pathology,in whom 73 patients（radiotherapy group）were treated with 6/15MV-X by conformal radiotherapy technique of 1.8 Gy/time,5 times/week,and the total dose were 61.2-64.8Gy.Another 95 patients（chemoradiotherapy group）were received chemotherapy（cisplatin 20mg d1-d5,5-FU 500mg/m2 d1-d5;for 4 cycles）and the same radiotherapy as radiotherapy group.Radiotherapy was given at the beginning of the second cycle of chemotherapy.Twenty-eight days was a cycle.Results Compared with patients＇ KPS scores in radiotherapy group,they were improved significantly in chemoradiotherapy group.The 3-years survival rate of chemoradiotherapy group was 17.9%,which was higher than that of radiotherapy group.Conclusion Chemoradiotherapy can improve quality of life for esophageal cancer patients invading trachea or main bronchus and extend their survival obviously.
出处
《临床肿瘤学杂志》
CAS
2010年第12期1113-1115,共3页
Chinese Clinical Oncology
关键词
食管癌
化学治疗
放射治疗
气管侵犯
Esophageal cancer
Chemotherapy
Radiotherapy
Invading trachea
