摘要
目的评定四肢骨肉瘤综合治疗的临床疗效。方法对我院2005年9月-2006年12月ⅡB期骨肉瘤患者36例进行临床随访,随访时间12-80(50.5±16)个月。全部患者均术前化疗3个疗程后手术,手术方式包括单纯扩大切除术4例、特制肿瘤假体30例、大段异体骨重建2例,术后化疗3-6个疗程。按照Huvos肿瘤坏死率分成两组,肿瘤坏死率<90%为A组,肿瘤坏死率≥90%为B组。结果两组间肿瘤复发率及转移率差异有统计学意义(P<0.05)。全部患者3年生存率为77.8%,其中A组生存率50%,B组生存率91.7%,两组之间差异有统计学意义(P<0.05)。结论肿瘤坏死率是评估生存率的重要指标,规范的大剂量多药联合化疗是骨肉瘤长期生存的重要保证。
Objective To evaluate the clinical effect of combined therapy for osteosarcoma of limbs.Methods Thirty-six patients with stageⅡB osteosarcoma admitted to our hospital in September 2005-December 2006 were followed up for 12-80（50.5±16）months.All patients underwent 3 courses of chemotherapy before operation.Of the 36 patients,4 underwent simple wide resection,30 received custom prosthesis,and 2 had large segment allograft reconstruction.Then they received 3-6 courses of post-operative chemotherapy.The patients were divided into group A（90% of the Huvos′ tumor necrosis rate） and group B（≥90% of the Huvos′ tumor necrosis rate）.Results The recurrent and metastasis rate had statistical significance between the two groups（P0.05）.The 3-year survival rate of the total patients was 77.8%,50% of group A,and 91.7% of group B,respectively（P0.05）.Conclusion Tumor necrosis rate is an important indicator for the evaluation of survival rate.Combined chemotherapy with multiple drugs at the standardized high dose is the key to a long survival time of patients with osteosarcoma of limbs.
出处
《军医进修学院学报》
CAS
2011年第4期319-320,共2页
Academic Journal of Pla Postgraduate Medical School
关键词
骨肉瘤
外科手术
肿瘤治疗方案
Osteosarcoma
Surgery Procedures
Operative
Antineoplastic Protocol
