摘要
目的:AnnexinⅠ是钙磷脂结合蛋白家族的一员,探讨AnnexinⅠ在慢性鼻咽炎、鼻咽癌组织中的表达及与鼻咽癌多项临床病理特征的关系。方法:采用免疫组织化学SABC法检测Annexin I在慢性鼻咽炎、鼻咽癌组织中的表达。结果:①Annexin I在鼻咽癌组织中的阳性表达率为29.55%,明显低于其在慢性鼻咽炎组织中的阳性表达率93.33%,差异具有显著性(P<0.01)。②Annexin Ⅰ的表达与鼻咽癌的组织分化程度有关(P<0.01),与临床分期、颅神经侵犯、颈淋巴结转移无相关性(P>0.05)。结论:AnnexinⅠ在鼻咽癌中的表达明显下调,鼻咽癌中Annexin I的表达与组织分化程度密切相关,Annexin I可能与鼻咽癌的发生发展有关。
Objective： AnnexinⅠis a member of the calcium and phospholipid-binding proteins superfamily.The purpose of this study was to investigate the expression of AnnexinⅠin chronic nasopharygitis and nasopharyngeal carcinoma,and the correlation between the expression of AnnexinⅠand the clinical pathological features of nasopharyngeal carcinoma.Method： The expression of Annexin I were detected using immunohistochemical staining（SABC）.Result： ①The AnnexinⅠlabeling frequency（29.55%） in nasopharyngeal carcinoma was significantly lower than that（93.33%） in chronic nasopharyngitis group（P 〈 0.01）,②AnnexinⅠexpression in nasopharyngeal carcinoma was correlated with histological grade（P 〈 0.01）,but not correlated with clinical stage,cranial nerve encroaching and lymph node metastases（P 〉 0.05）.Conclusion： The expression of AnnexinⅠis obviously down-regulated in human nasopharyngeal carcinoma and its expression is related with the histological differentiation status of human nasopharyngeal carcinoma,It is suggested that AnnexinⅠmay be involved in the development of human nasopharyngeal carcinoma.
出处
《河北医学》
CAS
2011年第3期311-315,共5页
Hebei Medicine
关键词
鼻咽癌
ANNEXIN
Ⅰ
免疫组化
Nasopharyngeal carcinoma
Annexin Ⅰ
Immunohistochemistry
