摘要
背景 乳化异氟烷（emulsified isoflurane,EI）是一种尚未应用于临床的新型麻醉药,它以30%的脂肪乳剂为载体,与异氟烷在一定条件下制成,可产生良好的麻醉作用.离体和在体动物实验研究表明EI预处理或后处理对多种器官具有保护作用.目的 综述El预处理或后处理的器官保护作用及其机制.内容 离体和在体动物实验研究表明,在一定浓度范围内,EI预处理或后处理对心、肺、脑及肝组织缺血/再灌注损伤均具有保护作用,并认为这可能是异氟烷本身作用所致;其机制涉及激活ATP敏感性钾通道、抑制NF-κB激活、抑制细胞凋亡、抗氧化等.趋向 作为一种新型静脉制剂,EI在重要器官保护方面将具有更好的临床应用前景.但目前所有研究仅处在动物实验阶段,要把它应用于临床还需深入研究.
Background Emulsified isoflurane （EI） is a new type of anesthetic which is still not clinically available. It consists of isoflurane and 30% of fat emulsion as carrier, which can provide good anesthetic effect. Both in vitro and in vivo animal studies have demonstrated that pre-or post-conditioning with EI can produce protective effects for many organs. Purpose To review organ protective effects and the mechanisms of pre- or post-conditioning with EI. Content It is demonstrated that, both in vitro and in vivo animal studies, pre- or post-conditioning with EI can produce protective effects on heart, lung, brain and liver from ischemia reperfusion injuries within a certain range of concentration. And it is supposed that these effects are resulted from isoflurane itself. The mechanisms involve the activation of ATP-sensitive potassium channels, inhibition of NF-κB activation, inhibition of apoptosis and anti-oxidation, etc. Trend As a new intravenous formulation, EI will have a better clinical application for vital organs protection. But all the studies at present only focused on animal experiments, much more further studies need to be done before it can be applied in the clinic.
出处
《国际麻醉学与复苏杂志》
CAS
2011年第2期247-249,共3页
International Journal of Anesthesiology and Resuscitation
关键词
乳化异氟烷
缺血预处理
再灌注损伤
Emulsified isoflurane
Ischemic preconditioning
Reperfusion injury
