摘要
目的研究当归补血汤对糖尿病肾病患者肾脏功能的影响,探讨其在糖尿病肾病（DN）防治中的意义;方法将符合条件的121例患者随机分为常规治疗组（对照组）和当归补血汤组（治疗组）（在对照组基础上另给予黄芪30g,当归6g,并根据中医症型加减）,治疗4周后对比两组的空腹血糖（FBS）、餐后两小时血糖、血尿酸（UA）、肌酐（Cr）、尿素氮（BUN）、糖化血红蛋白（HbA1C）、体重指数（BMI）、24h尿微量白蛋白等的变化情况;结果当归补血汤治疗组肾功能改善优于对照组（P〈0.05）,24h尿微量白蛋白排出明显低于对照组（P〈0.01）,但在BMI、FBS、HbA1C及餐后两小时血糖疗效无差别（P〉0.05）;结论归补血汤能改善糖尿病肾病患者肾功能,减少尿蛋白的排出。
Objective To investigate the effective of Angelicae Sinensis Decoction for Supplementing Blood（one kind of traditional prescription of chinese herbal medicine） on renal functions in patients with diabetic nephropathy,and explore the significance of the prevention and treatment in diabetic nephropathy.Method The 121eligible patients were randomly divided into conventional treatment group（control group） and and Angelicae Sinensis Decoction for Supplementing Blood group（treatment group）（based on the control group,given Astragalus 30g,Angelica 6g disease according to type addition and subtraction,modified according to the illness of Chinese medicine type）,comparing the two groups after 4 weeks of treatment,fasting blood glucose（FBS）,postprandial two-hour blood glucose,serum uric acid（UA）,creatinine（Cr）,blood urea nitrogen（BUN）,glycated hemoglobin（HbA1C）,body mass index（BMI）,24-hour urine albumin and other changes;Results The group of Angelicae Sinensis Decoction for Supplementing Blood improved renal function than the control group（P0.05）,24-hour urine albumin was significantly lower than the control group discharge（P0.01）,but BMI,FBS,HbA1C,and the postprandial two-hour blood glucose effect of no difference（P0.05）;Conclusion Angelicae Sinensis Decoction for Supplementing Blood Can improve renal function in patients with diabetic nephropathy,reduce urinary protein excretion.
作者
周必发
陆备军
陈明军
周雪玲
张莹雯
ZHOU Bi-fa,LU Bei-jun,CHEN Ming-jun,ZHOU Xue-ling,ZHANG Ying-wen（1.The Third People＇s Hospital of Cixi,Cixi 315324,China;2.Department of Integrated Traditional Chinese and Western Medicine,Centre-south Hospital,Wuhan University,Wuhan 430071,China）
出处
《医学信息》
2011年第7期1916-1917,共2页
Journal of Medical Information
基金
浙江省慈溪市科技局科研课题（编号：CN2009011）
关键词
当归补血汤
糖尿病肾病
肾脏
Angelicae Sinensis Decoction for Supplementing Blood
Diabetic Nephropathy
Kidney
