摘要
血管活性肽是构成循环系统自稳态调节的物质基础,能够调节血管平滑肌细胞舒缩功能、维持血管张力,多数以自分泌、旁分泌方式发挥作用,并按其血管效应的不同分为缩血管肽和舒血管肽.生理条件下,血管舒-缩活性肽之间存在着复杂的正反馈或负反馈调节,由此构成一个精细、严密的血管张力调控网络.其平衡失调会导致冠状动脉粥样硬化性心脏病、高血压等疾病的发生.阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea syndrome,OSAS）是一种全身性疾病,可对多脏器造成严重损害;内皮素-1、血管紧张索Ⅱ,心钠肽和脑钠肽、降钙素基因相关肽等是目前发现的主要的血管活性肽,研究发现缩血管活性肽与舒血管活件肽的失衡可能是OSAS患者心脑血管疾病的基础,但艿机制目前尚未十分明了并存在争议,作为涉及缺氧、内分泌及神经调节异常、炎症、氧化应激等多种病理过程的OSAS,可能存在着复杂的致病因素.现对上述主要的血管活性肽与OSAS的研究作一综述,以了解其间的关系.
Vasoactive peptide are the material foundation which constitute the circulatory system self-stability adjustment. They are a kind of low molecular weight peptide that regulate the vasodilative and vasoconstrictive function and maintain the vascular tone through the way of autocrine and （or） paracrine. There are dynamic equilibtium in the excretion and activity betwccn vasoconstrictive peptides and vasodilative peptides. The complcx positive feedback or negative feedback exists in different vasoactive peptides, which forms a network of regulation of vascular tone. Their balance disorders can lead to coronary heart disease, hypertension,etc. Obstruction sleep apnea syndrome （OSAS） is a systemic disease, which can cause severe damage to multiple organ. Endothelin-Ⅰ, angiotensin Ⅱ , atrial natriuretic peptide and brain natriuretic peptide, calcitonin gene related peptide are currently found the major vasoactive peptides, vasoconstrictive peptides and vasodilative peptides, imbalances might be OSAS patients disease of heart and head blood-vessel foundation, but its mechanism has not quite clear and controversial up to now, as involving ischemia, endocrine and neuromodulation abnormal, inflammation,oxidative stress and so on many kinds of the pathologic process, OSAS may exist complex pathogenic factors. This article sum up the research of the major vasoactivc peptide and OSAS in order to realize their relationship.
出处
《国际呼吸杂志》
2011年第7期544-546,共3页
International Journal of Respiration
