摘要
目的研究热休克蛋白70(HSP70)在外生殖器鳞癌(External-Genitalia Squamous Cell Carcinoma,EGSCC)的表达及临床意义。方法采用免疫组化技术检测15例正常外生殖器组织、31例EGSCC石蜡包埋组织HSP70蛋白的表达。结果 EGSCC组织中HSP70阳性表达率70.9%(22/31),低于正常外生殖器组织中100%的阳性表达率(t'=-7.327,P<0.05),差异有显著性统计学意义。随着疾病的进展,有明显的嗜基底膜细胞染色,HSP70阳性表达与临床分期、组织分化程度无明显相关性。结论 HSP70在EGSCC中的表达较正常组织低,提示HSP70与外生殖器鳞癌有关。
Objective To investigate the expression and clinical significance of HSP70 protein in external-genitalia squamous cell carcinoma（EGSCC）.Methods The expression of HSP70 protein was examined in 15 normal tissues and 31 cases with EGSCC by immunohistochemistry.Results The expression rate（100%,31/31）of HSP70 protein in normal tissue was more greater than that of the expression rate（70.9%,22/31） of HSP70 protein in EGSCC（t＇=-7.327,P=0.0000.05）.There was obvious expression in basilar membrane cell with disease progressed.HSP70 showed no correlation with clinic staging and pathological grade.Conclusion The expression of HSP70 protein in EGSCC is lower than that in normal tissue,which indicate that HSP70 may have relationship with EGSCC.
出处
《宁夏医科大学学报》
2011年第2期136-137,140,F0004,共4页
Journal of Ningxia Medical University
关键词
外生殖器鳞癌
热休克蛋白70
external-genitalia squamous cell carcinoma
heat shock proteins 70
