摘要
目的观察益气活血方对实验性大鼠子宫增生的抑制作用。方法将3月龄未孕雌性大鼠随机分为空白对照组、模型对照组、阳性给药组0.465 g/(kg.d)、益气活血方高剂量给药组40 g/(kg.d)、低剂量给药组10 g/(kg.d)。用苯甲酸雌二醇加黄体酮肌肉注射方法对模型对照组、阳性给药组、益气活血方高、低剂量给药组进行子宫肌瘤模型的复制,1周后同时对给药组分别灌胃给予受试药益气活血方和阳性对照药桂枝茯苓胶囊,5周后测各组的血液流变学指标,解剖大鼠取出子宫,计算子宫系数,并对子宫进行病理组织形态学观察。结果益气活血方能抑制模型大鼠子宫的扩大及瘤样增生和改善血凝状态。结论益气活血方具有预防和治疗子宫肌瘤的作用。
OBJECTIVE To investigate the effects of Yiqi Huoxue Fang（YQHXF） on the experimental model of uterine leiomyoma in rat.METHODS 70 Wistar unpregnancy 3-month-old female rats were randomly divided into 3 groups：model group,positive control group,therapy group.Estradiol benzoate and progesterone were administrated by intramuscular injection once a day to establish rat hysteromyma model,one week later YQHXF of different concentrations（40g/kg,10g/kg） and Guizhi Fuling capsule（GFC） as positive medicine（0.465g/kg） and then blood rheology index was tested and the rats were dissected to get the uteri whose index were calculated.Patho-histomorphology of uterus was also detected.RESULTS YQHXF restrained the excess proliferation of the smooth muscle of uterus and suppressed dilation of uteri in hysteromyma rats and improved blood coagulation.CONCLUSION YQHXF has preventive and therapeutic influence on hysteromyoma.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2011年第2期192-194,共3页
Journal of Nanjing University of Traditional Chinese Medicine
关键词
子宫
益气活血方
血液流变学
苯甲酸雌二醇
黄体酮
hysteromyoma
Yiqi Huoxue Fang（YQHXF）
hemorrheology
pathohistology
benzestrofol
flavolutan
