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芪附汤对阿霉素心脏毒性损伤的保护作用及其抗氧化机制 被引量:7

Protective Effect and Antioxidant Mechanism of Qifu Decoction on Adriamycin-induced Cardiac Injury
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摘要 目的:观察芪附汤对阿霉素心脏毒性损伤模型大鼠心脏功能的影响,并初步探讨其作用机制。方法:采用心电图仪测定心脏功能的相关参数,采用化学比色法检测心肌细胞超氧化物歧化酶(superoxide dismutase,SOD)和谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)活性及脂质过氧化产物丙二醛(malondialdehyde,MDA)含量。结果:与正常组相比较,模型组大鼠心率显著减慢,QRS波群电压明显降低,Q-T间期明显延长,均有统计学意义(P<0.05),个别出现心律失常;与模型组相比较,芪附汤组、中药对照组心率增加,QRS波群电压和明显增高,Q-T间期显著缩短,均有统计学意义(P<0.05)。与正常组相比较,模型组、芪附汤组、中药对照组心肌细胞SOD和GSH-Px活性减弱,MDA含量上升,均有统计学意义(P<0.05);与模型组相比较,芪附汤组、中药对照组心肌细胞SOD和GSH-Px活性增强,MDA含量下降,均有统计学意义(P<0.05)。结论:芪附汤对阿霉素诱导的大鼠心脏毒性损伤具有保护作用,作用机制与其抗氧化应激有关。 Objective:To investigate the effect of Qifu Decoction on heart function of adriamycin-induced cardiac injury in a rat model,and to discuss the mechanism.Method:Heart function was measured by ECG instrument,the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) were detected,and the content of lipid peroxidation product malondialdehyde(MDA) were checked by chemical colorimetric method.Result:Compared with the normal group,the heart rate of the rats in the model group was slowed down,the sum of QRS voltage decreased,Q-T interval extended,all with statistically significance(P 〈 0.05).Arrhythmia appeared in a few individuals.Compared with the model group,the heart rate of the rats in Qifu Decoction group and Chinese herb control group was speeded up,the sum of QRS voltage increased,Q-T interval shortened,all with statistically significance(P 〈 0.05).Compared with the normal group,the activities of SOD and GSH-Px were weakened,and the content of MDA increased in the model group,Qifu Decoction group and Chinese herb control group,all with statistically significance(P 〈 0.05).Compared with the model group,the activities of SOD and GSH-Px were strengthened,and the content of MDA decreased in Qifu Decoction group and Chinese herb control group,all with statistically significance(P 〈 0.05).Conclusion:Qifu Decoction can protect the heart from adriamycin in the rat model.Its mechanism may be related with antioxidant stress.
出处 《中国实验方剂学杂志》 CAS 北大核心 2011年第8期193-196,共4页 Chinese Journal of Experimental Traditional Medical Formulae
基金 辽宁省教育厅高等学校创新团队项目(2007T117)
关键词 芪附汤 阿霉素 心脏毒性 氧化应激 Qifu Decoction; adriamycin; cardio-toxicity; oxidative stress;
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