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前列地尔联合甲钴胺治疗2型糖尿病周围神经病变的疗效观察 被引量:18

Efficacy Observation of Alprostadil Combined with Mecobalamine in the Treatment of Type 2 Diabetic Peripheral Neuropathy
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摘要 目的:观察前列地尔联合甲钴胺治疗2型糖尿病周围神经病变的有效性和安全性。方法:选择2型糖尿病周围神经病变患者104例,随机分为对照组(50例)和观察组(54例)。2组除了给予常规药物控制血糖外,均给予甲钴胺0.5mg,tid,口服;观察组则在对照组基础上加用前列地尔10μg,qd,静脉滴注;2组均2周为1个疗程。观察2组治疗后症状改善、正中神经(MN)和腓总神经(CPN)的运动神经传导速度(MNCV)与感觉神经传导速度(SNCV)、药品不良反应等。结果:观察组与对照组显效率分别为48.1%和22.0%;总有效率分别为81.4%和60.0%,2组比较差异有统计学意义(P<0.05)。2组治疗前MNCV和SNCV比较,差异无统计学意义(P>0.05)。2组治疗2周后MNCV、SNCV与治疗前比较,差异有统计学意义(P<0.05);治疗2周后观察组MNCV、SNCV与对照组比较,差异有统计学意义(P<0.05)。2组均未见严重药品不良反应。结论:前列地尔联合甲钴胺治疗2型糖尿病周围神经病变有效且安全性良好。 OBJECTIVE:To observe the effectiveness and safety of alprostadil combined with mecobalamine in the treatment of type 2 diabetic peripheral neuropathy(DPN).METHODS:104 patients with type 2 diabetes complicating with DPN were randomly divided into control group and observation group.Both groups were treated with regular glycemic control drugs and oral dose of mecobalamine 0.5 mg,tid.Observation group were additionally treated with alprostadil 10 μg,qd via i.v.gtt for 2 weeks.The improvement of symptom,motor nerve conduction velocity(MNCV) and sensory nerve conduction velocity(SNCV) of median nerve(MN) and common peromeal nerve(CPN),drug adverse reaction of 2 groups were observed.RESULTS:The obvious effective rates of observation group and control group were 48.1% and 22.0%(P0.05),there was statistical difference.The total effective rates of 2 groups were 81.4% and 60.0%(P0.05),there was statistical difference.There was no statistical difference in MNCV and SNCV between 2 groups before treatment(P0.05).2 weeks after treatment,MNCV and SNCV of 2 groups were both higher than before treatment(P0.05),there was statistical difference.2 weeks after treatment MNCV and SNCV of observation group were higher than those of control group(P0.05),there was statistical difference.There was no severe drug adverse reaction in 2 groups.CONCLUSION:Alprostadil combined with mecobalamine is effective and safe in the treatment of DPN.
作者 付晶晶 赵娟
出处 《中国药房》 CAS CSCD 北大核心 2011年第16期1468-1470,共3页 China Pharmacy
关键词 2型糖尿病 周围神经病变 前列地尔 甲钴胺 Type 2 diabetes Peripheral neuropathy Alprostadil Mecobalamine
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参考文献8

  • 1郭英,郑世良,惠宗光,黄文波.弥可保对糖尿病周围神经病变神经传导速度的影响[J].山东医药,2007,47(27):145-146. 被引量:9
  • 2刘淑娟,王玉红,王秀萍.川芎嗪联合弥可保治疗糖尿病周围神经病变65例观察[J].山东医药,2006,46(31):52-52. 被引量:6
  • 3徐磊.葛根素治疗糖尿病周围神经病变疗效观察[J].中国误诊学杂志,2003,3(2):250-251. 被引量:8
  • 4Kashyap AS,Anand KP,Kashyap S,et al.Peripheral ne-uropathy. The Lancet . 2004
  • 5Boulton A J,Vinik A I,Arezzo J C,et al.Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care . 2005
  • 6Gaede P,Vedel P,Larsen N,et al.Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. New England Journal of Homeopathy . 2003
  • 7Paul V,Claude LDJ,ean LRe,t al.A multicenterd,ouble-blinds,afety study 0f QR-333 for the treatment 0f symp-tomatic diabetic peripheral neuropathy.a preliminary report. Diabetes Complications . 2005
  • 8Akahori H,Takamura T,Hayakawa T, et al.1</sub> in lipid microspheres ameliorates diabetic peripheral neuropathy: Clinical usefulness of Semmes-Weinstein monofilaments for evalu-ating diabetic sensory abnormality&amp;sid=Diabetes Research and Clinical Practice&amp;aufirst=Akahori H');&#xA; ">Prostaglandin E<sub>1</sub> in lipid microspheres ameliorates diabetic peripheral neuropathy: Clinical usefulness of Semmes-Weinstein monofilaments for evalu-ating diabetic sensory abnormality. Diabetes Research and Clinical Practice . 2004

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