摘要
目的探讨拉莫三嗪对难治性精神分裂症患者认知功能的影响。方法采用入院顺序分层随机法,将80例难治性精神分裂症患者平均分为研究组(拉莫三嗪+利培酮)和对照组(利培酮+安慰剂)。在治疗前和治疗后2、4、8、12周末,用阳性症状及阴性症状量表(PANSS),不良反应量表(TESS)评定疗效及副反应,用韦氏成人智力量表(WAIS-R)、韦氏记忆量表(WMS)评定治疗前后患者认知功能的改变。分析量表中各领域的计分。结果两组PANSS总分在治疗后与治疗前比较差异存在统计学意义(P<0.05),研究组有效率72.5%,显效率20%;对照组有效率52.5%,显效率12.5%。两组间疗效差异有统计学意义(P<0.05),且两组言语量表、操作量表、全量表和记忆量表分比治疗前明显提高,研究组与对照组比较差异有统计学意义(P<0.05)。治疗后2、4、8、12周末TESS评分,两组差异无统计学意义(P>0.05)。结论拉莫三嗪合并利培酮治疗难治性精神分裂症疗效确切,且安全性高,对认知功能的改善彻底。
Objective To investigate the effect of Lamotrigine （LTG） on cognitive function in patients with refractory schizophrenia. Methods Being used a stratified random method according to the order of admission, 80 patients with refractory schizophrenia were divided into study group （LTG ＋ risperidone） and control group （risperidone ＋ placebo）. The Positive and Negative Syndrome Scale（PANSS） and treatment emergent symptom scale（TESS） were used to evaluate the efficacy and side effects respectively at baseline and at the end of 2,4,8,12 weekends; The Wechsler Adult Intelligence Scale （WAIS-R）and Wechsler Memory Scale （WMS）were used to assess the cognitive function in patients with refractory schizophrenia before treatment and after 2、4、8、12 weeks＇treatment. The scale scores in every domains were analysed statistically. Results After treatment,the total scores of PANSS in both groups were significantly different than before （P0.05）. The efficacy rate of study group was 72.5%,in which 20 % were improved markedly;while efficacy rate and markedly effective rate of control group was 52.5% and 12.5% respectively.The efficacy between both groups were significantly different （P0.05）. The scores in verbal scale, operating scale, full scale and memory scale of both groups were significantly improved compared with before,and there were significant difference between both groups （P0.05）. The scores of TESS had no significant difference between both groups after 2,4,8,12 weeks＇ treatment. Conclusion Lamotrigine combined risperidone for treating refractory schizophrenia is effective, has higher safety, and it can improve the cognitive function thoroughy.
出处
《中国实用医药》
2011年第8期3-5,共3页
China Practical Medicine
