摘要
目的： 探讨消炎Ⅰ号方治疗葡萄膜炎的作用机理。方法： 实验兔随机分为正常组和实验性葡萄膜炎消炎Ⅰ号方治疗组、激素治疗组、生理盐水对照组。在不同阶段用放射免疫法对各组房水及外周血中白细胞介素Ⅱ（ｉｎｔｅｒｌｅｕｋｉｎＩＩ，ＩＬＩＩ） 和肿瘤坏死因子（ｔｕｍｏｒｏｕｓ ｎｅｃｒｏｔｉｃｆａｃｔｏｒα， ＴＮＦα） 进行检测。结果： 与正常组比较， 葡萄膜炎兔外周血及房水中ＴＮＦα升高； 与生理盐水组比较， 激素组外周血及房水ＴＮＦα、房水中ＩＬ２ 降低； 中药组外周血ＴＮＦα及房水中ＩＬ２ 降低， 差异均有显著性（ Ｐ＜ ０－０５）。房水中ＴＮＦα含量虽降低， 差异无显著意义。结论：消炎Ⅰ号方在一定程度上有抑制实验性葡萄膜炎兔ＴＮＦα和降低ＩＬＩＩ水平的作用。
OBJECTIVE:To investigate mechanism of xiaoyan yihaofang (消炎Ⅰ号方) in the treatment of experimental uveitis. METHODS: Experimented rabbits were divided into normal group, treated group with xiaoyan yihao fang, group with corticosteroid, and control group with normal normal saline. To detect level of interleukin II (IL II) and tumorous necrotic factor (TNF α) collected from the aqueous and peripheral blood of rabbits with experimental uveitis, a radio-immunity method was applied in the each group. RESULTS: Compared with normal group, content of TNF α was increased in aqueous and blood of the rabbits with uveitis. Compared with normal saline group, content of TNF α in the aqueous and blood, and content of IL 2 in the aqueous were decreased obviously in the group treated with corticosteroid. Content of TNF α in the blood and content of IL 2 in the aqueous were decreased in the group treated with xiaoyan yihaofang group. There was a significant difference between the control group and treated groups ( P <0 05). CONCLUSION: Xiaoyan yihaofang could be effective on inhibition the level of TNF α and IL II in the rabbits with experimental uveitis.
出处
《中国中医眼科杂志》
1999年第4期195-197,共3页
China Journal of Chinese Ophthalmology
关键词
中医药疗法
实验性
葡萄膜炎
肿瘤坏死因子
rabbit
experimental uveitis
interleukin (IL II)
tumorous necrotic factor (TNF)
