摘要
目的:考查大黄素与姜黄素、苦参碱配伍后对小鼠致畸敏感期的影响。方法:性成熟KM种小鼠雌雄合笼交配,将孕鼠随机分成低、中、高三个剂量组和阴性对照组,观察母鼠和胎鼠的生长发育情况。结果:受试药物各剂量组的孕鼠增重、活胎体重、身长、尾长、死胎数、吸收胎数、畸形率(包括外观畸形、内脏畸形和骨骼畸形)和空白对照组间的所有指标差异均无统计学意义(P>0.05)。结论:大黄素配伍这些中药成分后在治疗剂量下对小鼠无母体毒性、胚胎毒性和致畸作用。
Objective ： To observe the effects of emodin combined with curcumin and matrine on mice sensitive period to teratogenie agent. Method ： The sexual maturation KM mice were mated and the pregnant ones were randomly divided into high, medium, low dose groups and negative control group. The growth of the maternal and embryo mice was observed. Result： There was no significant difference between the three dose groups and control group in all observed indices including body weight gain of pregnant mice, body weight, body length and tail length of embryo mice, the number of death embryos and absorption embryo mice and the malformation rate of embryo mice （ appearance, viscera and skeleton） （ P 〉 0. 05 ）. Conclusion ： Emodin combined with curcumin and matrine shows no toxic and teratogenic effects on maternal and embryo mice.
出处
《中国药师》
CAS
2011年第4期457-459,共3页
China Pharmacist
基金
湖北省科技厅自然科学基金(编号:2009CDZ104)
