摘要
对近几年双黄连注射液主要致敏原研究的主要进展进行了回顾,提出了双黄连注射液导致过敏性休克的个体差异与HLA基因多态性有密切关系。基于此,提出以基因指纹学说为基础,研究双黄连注射液重要致敏原易感基因的研究策略,为今后探讨双黄连注射液主要致敏原与HLA-DRB基因多态性、特异性IgE抗体之间的相互关系,明确有关双黄连注射液致过敏反应的基因位点,为研究双黄连注射液过敏反应机制、临床预防中药过敏反应提供参考依据,为中药注射剂致敏机制研究提供思路。
Reviewing the progress on study about the major allergen of Shuanghuanglian injection in recent years, resulted in that individual differences of anaphylactie shock are closely related with HLA gene polymorphism. Basing on this, we put forward the research strategy on susceptibility gene of important allergen of Shuanghuanglian injection based on the theory of genetic fingerprints, in order to make sure about the relationship the major allergen of Shuanghuanglian injection and HLA-DRB gene polymorphism and specificity IgE antibody, and to clarify the allergic reaction loci reduced allergic reactions, which can provide the reference data for the study on mechanisms for anaphylactie reaction of Shuanghuanglian injection, and research ideas for the sensitization mechanism of traditional Chinese medicine injection study.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2011年第8期1106-1108,共3页
China Journal of Chinese Materia Medica
基金
科技部"重大新药创制"科技重大专项(2009ZX09502-030)
中国中医科学院自主选题(Z02101)
