摘要
目的探讨单纯乳腺粘液癌病理临床特征、治疗和预后。方法回顾性分析2004年1月至2010年12月收治的单纯乳腺粘液癌的临床病理资料。结果25例单纯乳腺粘液癌占同期治疗女性乳腺癌960例的2．6％，年龄32～81岁，平均（55．28±15．73）岁，肿瘤大小1～10cm，腋淋巴结阳性率0％，免疫组化检测雌激素（ER）、孕激素（PR）、HER-2和p53的阳性率分别为96％、92％、0％和32％。全组行手术和辅助化疗（环磷酰胺＋阿霉素、紫杉醇＋阿霉素）。12例服用三苯氧胺，13例服用来曲唑，8例行放射性治疗。随访时间1～6年，平均3．5年，总生存率为100％。结论单纯乳腺粘液癌恶性程度低，预后较好，选择适当的尽量减少创伤的手术方式和辅助治疗。分子生物学指标在预后中的作用应受到足够的重视。
Objective To explore clinical characteristics, pathology, prognosis and proper treatment of pure muclnous breast carcinoma （ PMBC ）. Methods Retrospective analysis was carried out on patients with PMBC who were admitted from Jan. 2004 to Dec. 2010. Results PMBC patients accounted for 2. 6% of all the patients with breast cancer treated at the same period. The mean age of PMBC patients was （55.28 ±15.73 ） years, ranging from 32 years to 81 years. The tumor diameter was from 1 to 10 cm and axillary lymph node involvement was 0%. Immunohistochemical detection showed the positive rate of estrogen receptor （ER） , proges- terone receptor （PR）, HER-2 and p53 was 96% , 92% , 0% and 32% respectively. All patients underwent operation and polychemotherapy （ eyclophosPhamide ＋ Adriamycin, Paclitaxcl ＋ Adriamycin ）. 12 cases received tamoxifen, 13 cases received letrozole and 8 cases received postoperative irradiation. All the patients were followed up from 1 month to 6 years and the overall survival rate was 100%. Conclusions PMBC is a favorable histological type of breast carcinoma with good prognosis. Proper surgical and adjuvant therapy is important to im- prove survival rate and life quality. Molecular biologic parameters should be given enough consideration into prognosis evaluation.
出处
《中华内分泌外科杂志》
CAS
2011年第2期114-116,共3页
Chinese Journal of Endocrine Surgery
关键词
单纯乳腺粘液癌
病理
治疗
预后
Pure mucinous breast carcinoma
Pathology
Treatment
Prognosis
