摘要
目的了解脑卒中后患者的抑郁程度及生活质量状况,并对抑郁的相关因素进行分析。方法对60例卒中后抑郁患者进行问卷调查,内容包括:年龄、性别、职业、性格、社会支持、卒中次数、病程、合并疾病、神经功能缺损程度;根据汉密尔顿抑郁量表评分将60例患者分为轻度抑郁组30例和中重度抑郁组30例,两组患者均在入组时和康复治疗6周后由同一医生用美国国立卫生研究院脑卒中量表(NIHSS)和WHO生存质量测定简式量表(WHOQOL-BREF)中文版分别对患者的神经功能和生活质量进行评定。结果经逐步回归分析:社会支持、神经功能缺损、合并疾病进入方程(P<0.05),其中社会支持影响最大;经Spearman相关分析,生活质量与抑郁程度、神经功能缺损、年龄、合并疾病、卒中次数呈负相关(P<0.05),与文化程度、社会支持呈正相关(P<0.05),其中抑郁程度的影响最大;经康复治疗后,轻度抑郁组的神经功能及生存质量的改善均明显优于中重度抑郁组,差异有统计学意义(P<0.05)。结论应积极干预加重卒中后抑郁的相关因素,从而促进神经功能的康复,提高患者的生存质量。
Objective To investigate the level of post-stroke depression and their quality of life（QOF） and analyze the associated factors.Methods Sixty patients with post-stroke depression completed a questionnaire-based survey,which include age,gender,career,personality,education,social support,times of stroke onset,course of disease,comorbidities,and neurological deficit.Patients were divided into mild group（n=30） and moderate/severe group（n=30） based on the severity of depression,which was assessed using Hamilton depressive scale.The neurological function and QOF were assessed with National Institute of Health Stroke Scale（NIHSS）and World Health Organization Quality of Life Assessment Instrument Brief Version（WHOQOL-BREF）before enrollment and 6 weeks after rehabilitative treatment,respectively,by the same doctor.Results Stepwise multiple regression analysis indicated that social support,neurological deficit,and comorbidities were significantly correlated with post-stroke depression and QOF（P0.05）.Spearman analysis indicated that there was a negative correlation between QOF and the depression level,neurological deficit,age,comorbidities,and times of stroke onset（P0.05）,and QOF was positively correlated with education and social support（P0.05）.Among them,the severity of depression was most influential.After rehabilitative treatment,the scores of NIHSS and WHOQOL-BREF were improved more significantly in mild depression group than in moderate/severe group（P0.05）.Conclusion The associated factors of post-stroke depression and QOF should be actively intervened to promote the recovery of nerve function and improve QOF.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第11期1167-1169,共3页
Chinese General Practice
基金
上海市残联科研基金资助项目(200910)
世界健康基金会资助项目(PH05520-01)
关键词
卒中
抑郁
生活质量
相关因素
Stroke
Depression
Quality of life
Associated factors
