摘要
目的探讨炎症性肠病(IBD)发病的危险因素。方法收集2007年7月—2010年5月温州医学院附属医院门诊及住院IBD患者150例为病例组,采用1:1配对法,选择同期在该院就诊、年龄和性别相匹配的无消化系统疾病患者150例为对照组。调查两组饮食习惯、文化程度、职业、家庭卫生情况、吸烟、母乳喂养、IBD家族史、肠道感染病史、阑尾切除术、麻疹、非甾体类药物使用等26个因素。统计方法采用多元回归分析。结果多元回归分析显示肠道感染史增加IBD的危险性〔OR=5.704,95%CI为(1.710,10.953)〕;牛奶摄入及职业紧张度也可增加IBD的危险性〔OR=3.624,95%CI为(1.474,8.907);OR=3.972,95%CI为(1.593,12.898)〕;喜食海鲜可降低IBD发生的危险性〔OR=0.78,95%CI为(0.121,2.309)〕。结论肠道感染史、牛奶摄入及职业紧张度为IBD发病的独立危险因素,喜食海鲜为IBD的保护因素。
Objective To investigate the risk factors of inflammatory bowel disease（IBD）.Methods Totally 150 patients with IBD（IBD group） and the same number of controls（control group） were enrolled between 2007 to 2010 in our hospital.A questionnaire was designed to survey 26 factors including diets,education,occupation,health status.smoking,breast feeding,family history of IBD,history of intestinal infection,appendectomies,measles,use of non-steroidal anti-inflammatory drugs（NSAID）.The results were analyzed using multivariate conditional Logistic analysis.Results Multivariate conditional Logistic regression analysis showed that the risk factors of IBD included history of intestinal infection（OR=5.704,95%CI（1.710,10.953））,milk（OR=3.624,95%CI（1.474,8.907））,and mental stress（OR=3.972,95%CI（1.593,12.898））.Sea food significantly reduced the morbidity of IBD（OR=0.78,95%CI（0.121,2.309））.Conclusion Intestinal infection history,milk,and mental stress are the independent risk factors of IBD,and seafood may be a protective factor.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第11期1188-1190,共3页
Chinese General Practice
基金
温州市科技局基金(Y20070080)
关键词
炎症性肠病
危险因素
病例对照研究
Inflammatory bowel disease
Risk factors
Case-control studies
