摘要
目的探讨2型糖尿病(T2DM)是否是原发性肝癌(PHC)发病的危险因素。方法选取2007—2009年在广西医科大学第一附属医院住院的PHC患者292例(病例组),并随机选取同期住院的非肝癌患者300例作为对照组。采用病例对照的方法,回顾性分析两组患者的糖尿病(DM)患病情况、乙型病毒性肝炎(乙肝)病史、吸烟、饮酒、PHC家族史的差异,并比较PHC合并DM组与PHC非DM组患者血生化指标的差异。结果病例组患者中合并DM者35例(12.0%),对照组患者中合并DM者21例(7.0%),两组比较差异有统计学意义(P=0.038)。病例组中,PHC合并DM患者发病年龄及三酰甘油(TG)水平显著高于PHC非DM者,而有乙肝病史者所占比例及ALT、AST水平均显著低于PHC非DM组,差异均有统计学意义(P<0.05)。单因素Logistic回归分析提示性别、年龄、吸烟、饮酒、乙肝、PHC家族史、DM与肝癌的发病有关,最终年龄、饮酒、乙肝、DM进入多因素非条件Logistic回归模型,其OR值分别是1.047、1.471、4.826和2.899。病例组及对照组乙肝患者中DM者分别有24例和5例,DM和乙肝协同诱导PHC危险性分析显示OR=2.942,P=0.023。结论年龄、饮酒与PHC有关,乙肝及DM是PHC的危险因素,且二者有协同作用。
Objective To explore the risk factors of primary hepatic carcinoma（PHC） after diabetes mellitus（DM）.Methods Totally 292 PHC patients（PHC group） and 300 patients without liver diseases（control group） who were admitted in our hospital from January 1,2007 to December 31,2009 were enrolled in this study.The prevalence of DM,smoking,drinking,HBV infection,and family history of liver cancer was compared between these two group.Furthermore,the biochemical findings were compared between PHC combined DM subgroup and PHC without DM subgroup.Results The incidence of DM was 12.0%（n=35） in PHC group and 7.0%（n=21） in control group patients（P=0.038）.In the PHC group,the onset age and triglyceride level were significantly higher in PHC combined DM subgroup than in PHC without DM subgroup,and the proportion of patients with a history of hepatitis B and serum ALT and AST levels were significantly lower（all P0.05）.Single factor Logistic regression analysis indicated that sex,age,smoking,drinking,HBV infection,family history of liver cancer,and DM were significantly correlated with PHC;age,drinking,HBV infection,DM entered the multifactor non-conditional Logistic regression model,and the OR values were 1.047,1.471,4.826,2.899.There were 24 patients from HPC group and 5 patients from control group had both hepatitis and DM,and the synergistic risk of DM and hepatitis in inducing PHC was significantly high（OR=2.942,P=0.023）.Conclusion Age and drinking are associated with PHC.HBV infection and DM are risk factors of PHC,and may exert synergistic effect.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第11期1191-1193,共3页
Chinese General Practice
关键词
糖尿病
原发性肝癌
危险因素
Diabetes mellitus
Primary hepatic carcinoma
Risk factors
