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胰岛素样生长因子-1在血管性痴呆中的作用

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摘要 血管性痴呆(VD)是痴呆的常见类型,是脑血管疾病造成的脑部损伤所致的智力损害综合征。胰岛素样生长因子-1(IGF-1)属于胰岛素家族,脑内IGF-1通过与其受体结合发挥促进神经元分化的作用。在脑缺血性损伤后,脑组织中IGF-1及其受体表达增加,能减少梗死面积,修复损伤的神经元。血管性痴呆患者组织病理学上有胆碱能活性降低,IGF-1是脑内胆碱能系统潜在调节因子。
作者 王本孝 许平
机构地区 皖北煤电集团总医院(蚌埠医学院第三附属医院)神经内科 皖南医学院弋矶山医院神经内科
出处 《国际神经病学神经外科学杂志》 2010年第6期514-516,共3页 Journal of International Neurology and Neurosurgery
关键词 胰岛素样生长因子-1 脑缺血 血管性痴呆
分类号 R749.13 [医药卫生—神经病学与精神病学]
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参考文献18

  • 1Reed BR, Munqas DM, Kramre JH, et al. Profile of neuro- psychological impair-ment in autopsy-defined Alzheimer dis- ease and cerebrovascular disease. Brain, 2007 , 130 ( 3 ) : 731-739.
  • 2Rosen CJ, Pollak M. Circulating IGF-1: New perspectives for a new century. TEM, 1999, 10(6) : 136-141.
  • 3Ange A, Ben C, Nevi F, et al. Insulin-like growth factor-1 ( IGF-1 ) : relationwith cognitive functioning and neuroimaging marker of brain damage in a sample of hypertensive eldly sub- jects. Arch Gerontol Geriatr, 2009, 49 ( Supple 1 ) : 5- 12.
  • 4Harada N, Narimatsu N, Kurihara H, et al. Stimulation of sensory neurons improves cognitive function by promoting the hippocampal production of insulin-like growth factor-1 in mice. Transl Res, 2009, 154(2) : 90-102.
  • 5Lin CM, Huang YL, Lin ZY. Influence of gender on serum growth hormone, insulin-like growth factor-1 and its binding protein-3 during aging. Yonsei Med J, 2009 , 50 ( 3 ) : 407-413.
  • 6石广滨,张昱,刘群,刘洪敏.胰岛素样生长因子-1对痴呆模型大鼠学习记忆能力影响及其可能机制[J].中风与神经疾病杂志,2009,26(1):25-27. 被引量：8
  • 7吴红瑛,罗仁,范建中,李川,魏轶.大鼠脑缺血再灌注后胰岛素生长因子1的表达[J].广东医学,2009,30(4):522-523. 被引量：3
  • 8Gustafson K, Hagberg H, Bengtsson BA, et al. Possible protective role of growth hormone in hypoxic- ischemia in neo- natal rats. Pediatr Res, 1999, 45(3) : 318-323.
  • 9Johnsen SP, Hundborg HH, Sorensen HT, et al. Insulin- like growth factor-Ⅰ, -Ⅱ, and IGF binding protein-3 and risk of ischemic stroke. J Clin Endocfinol Metab, 2005, 90 (11): 5937-5941.
  • 10黄延焱,卢晓喆,俞茂华.血清中胰岛素样生长因子-1水平与脑卒中后痴呆关系的研究[J].中华老年心脑血管病杂志,2007,9(5):304-307. 被引量：4

二级参考文献47

  • 1韩怡凡 陈先瑜.中枢胆碱能递质系统与学习记忆关系的研究[J].生理科学进展,1983,14(3):220-220.
  • 2Ridley RM, Baker I-IF. Evidence for a specific information processing deficit in monkeys with lesions of septo-hippocampal system [ J]. Cortex, 1997,33 ( 1 ) : 167-176.
  • 3Beilharz E J, Russo VC, Butler G, et al. Coordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic ischemic injury[ J]. Brain Res Mol Brain Res, 1998, 59( 1 ) :119-134.
  • 4肖信生.神经递质与中枢神经系统疾病[M].南京大学出版社,1998.87.
  • 5Muir JL. Acetylcholine, aging, and Alzheimer's disease [ J ]. Pharmacol Biochem Behav,1997,56(4) :687-696.
  • 6Lyness SA, Zarow C, Chui HC. Neuron loss in key cholinerglc and aminergic nuclei in Alzheimer disease: a meta-analysis [ J ]. Neurobiol Aging,2003,24( 1 ) :1-23.
  • 7Masliah E, Terry RD, Alford M, et al. Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease[J]. Am J Pathol, 1991,138 ( 1 ) :235-246.
  • 8Lupien SB, Bluhm E J, Ishii DN. Systemic insulin-like growth factor-Ⅰ administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats [ J ]. J Neurosci Res,2003,74(4) :512-523.
  • 9Arai Y,Hirose N,Yamamura K,et al. Serum insulin-like growth factor-1 in centenarians : implications of IGF-1 as a rapid turnover protein [J]. J Gerontol A Biol Sci Med Sci,2001,56(2) :79-82.
  • 10Guan J, Williams C, Gunning M, et al. The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats [ J ]. J Cereb Blood Flow Metab,1993,13(4) : 609-616.

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国际神经病学神经外科学杂志
2010年 第6期

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