摘要
目的:探讨中国人群IL-1基因多态性与胃癌发生的相关性。方法:通过检索MEDLINE、Embase、Cancerlit、AACR(American association for cancer re-search)、中国生物医学文献数据库(CBM-disc)、中国知网、万方数据库等数据库,纳入16个关于IL-1-31,IL-1B-511,和IL-1RN基因多态性和胃癌相关性的病例对照研究。采用Rev Man 4.2.2统计软件进行文献的异质性检验并计算合并效应优势比(OR)和95%可信区间(CI)。结果:经筛选纳入16个病例-对照研究,其中包含2 099例胃癌病例和2 371个正常对照,IL-1B-31C,IL-1B-511T和IL-1 RN 3个位点的OR和CI分别是〔OR=0.98,95%CI(0.72～1.34);P=0.89〕、〔OR=1.45,95%CI(1.00～2.09);P=0.05〕、〔OR=1.61,95%CI(0.97～2.67);P=0.07〕。结论:在中国人群中,IL-1B-31和IL-1RN两位点基因多态性与胃癌发生不存在关联性,IL-1B-511位点基因多态性与胃癌发生易感性相关联。
OBJECTIVE：To examine the association between IL-1 genotype and gastric cancer by systematically reviewing the risk of the original studies in the Chinese population.METHODS：Searching databases such as the MEDLINE,Embase,Cancerlit,AACR（American association for cancer research）,CBMdisc,CNKI,WANFANG DATA etc,yielded 16 case-control studies that reported on the association between IL-1B-31 C,IL-1B-511 T,or IL-1 RN variable number tandem repeat polymorphisms and gastric cancer risk.Summary odds ratios（OR）,95% confidence intervals（95%CI） and overall effect P value were calculated in the random-effects model by using the Der Simonian-Laird method with RevMan 4.2.2 software.RESULTS：Sixteen studies,which included 2 099 gastric cancer cases and 2 371 controls,met the inclusion criteria and were included in the Meta-analysis.By pooling all the studies identified,the summary odds ratio（OR） of gastric cancer risk associated with IL-1B-31C,-511T and IL-1 RN was（0.98（95%CI：0.72-1.34）,P=0.89）,（1.45（95%CI：1.00-2.09）,P=0.05） and（1.61（95%CI：0.97-2.67）,P=0.07）,respectively.CONCLUSION：In this systematic review,IL-1B-31 and IL-1 RN genetic polymorphisms are not associated with an increased risk of developing gastric cancer in the chinese population,but IL-1B-511 genetic polymorphism is associated with the susceptibility of gastric cancer.
出处
《中华肿瘤防治杂志》
CAS
2010年第21期1705-1710,共6页
Chinese Journal of Cancer Prevention and Treatment
